実用化された完全自動化血漿冷却濾過装置(<特集>肝・膵疾患とアフェレシス)

概要

論文の詳細を見る
Cryofiltration required a large cooling box and a complicated washing procedure for reuse of the second filter in the past. The plasma separator and cooling system were also separated. We have developed a new automatic cryofiltration system. We used a refrigerator or a liquid coolant for cooling plasma, but these systems had the problems of occupying excessive space and cooling efficiency. To solve them, we adopted a pertier element for cooling. A thin cooling bag is sandwiched between two cooling plates which make up the pertier element. This system enables compact packaging and maintains a constant temperature, and temperature can be changed easily. Furthermore, adoption of the pertier element permits the cryofiltration system to be contained in one unit. In washing out cryogel from the second filter, the manual procedure was so complicated that we developed an automatic removal system. When the pressure of the second filter goes up to 300 mmHg, cryogel in the second filter is washed out automatically with saline solution. This new system can provide other modes such as double-filtration plasmapheresis, plasma exchange and plasma adsorption.
日本アフェレシス学会の論文
1997-10-31