置換液選択の意義

概要

論文の詳細を見る
Substitution fluid is used to correct the water, electrolyte and acid-base imbalance upon hemofiltration (HF) and hemodiafiltration (HDF). These therapies eliminate a lot of water and electrolyte into ultrafiltrate with toxic substances accumulated in the body. Substitution fluid replaces the water and electrolyte depleted during HF and HDF. To correct the acid-base imbalance of critically ill patients by continuous HF or HDF, bicarbonate should be applied for the alkalizing agent of the substitution fluid. For plasma purification therapies, human plasma components are used for replacement fluid. Fresh frozen plasma (FFP) is the most common agent for replacement because it supplies all of the physiological plasma components, but high cost and inevitable risk of infection are serious problems. To resolve the problems, solutions containing human albumin are available for double-filtration plasmapheresis and plasma adsorption therapies. It is very important to select an adequate kind and amount of replacement or substitution fluid, not only for safety and economy but also for the efficiency of blood purification therapy.
日本アフェレシス学会の論文
1999-02-28