ビタミンB_2及びB_6欠乏シロネズミの組織におけるビタミンB_2とB_6の相互関連性

概要

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The inter-relationship between vitamin B_2 and B_6 was investigated using vitamins B_2. B_6 and B_2-B_6 double deficient rats. 1. Vitamin B_2 deficiency produced increase in the activities of GOT and GPT in epidermis and that of GPT in liver but had no effect on vitamin B_6 levels in tissues. 2. Vitamin B_6 deficiency produced increase in the level of vitamin B_2 in liver but had no effect on the activities of glutathion reductase (GR) in tissues. 3. Vitamins B_2-B_6 double deficiency produced decrease in the activities of GPT and the levels of vitamins B_2 and B_6 in all tissues examined, while the activity of GR was only decreased in erythrocyte. 4. By feeding vitamin B_2 to B_2-B_6 double deficient rats, the body weight gain and histological skin lesions were slightly improved, compaired to vitamin B_2 deficient ones but were inferior to vitamin B_6 deficient ones; the activity of GR in erythrocyte and the level of vitamin B_2 in epidermis were not recovered to the control level.
日本ビタミン学会の論文
1980-12-25