Synthesis of (R)- and (S)- Muscone(Organic Chemistry)
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概要
- 論文の詳細を見る
(R)-(-)-Muscone (3-methylcyclopentadecanone, 1) the key perfumery component isolated from the male musk deer, Moschus moschiferus,^* was synthesized from the easily available chiral building block, (R)-3-tert-butoxycarbonyl-2-methylpropanoic acid (2), by employing ring-closing olefin metathesis (RCM). Antipode (+)-1 was also synthesized in a similar manner from tert-butyl (S)-3-methoxycarbonylbutanoate (10). ^*(a) Walbaum, H. J. J. Prakt. Chem., 73, 488 (1906) ; (b) Ruzicka, L., Further considerations on the constitution of muscone. Helv. Chim. Acta, 9, 715, 1008-1017 (1926).
- 社団法人日本農芸化学会の論文
- 2002-06-23
著者
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Kitahara Takeshi
Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Science The
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Fujimoto Satoko
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Itoh Masamichi
Technical Research Center T. Hasegawa Co. Ltd.
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YOSHIKAWA Keisuke
Technical Research Center, T. Hasegawa Co. Ltd.
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Yoshikawa Keisuke
Technical Research Center T. Hasegawa Co. Ltd.
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Kitahara Takeshi
Department Of Agricultural Chemistry The University Of Tokyo
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Kitahara Takeshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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