Effect of Composition on the Stability of Liposomal Irinotecan Prepared by a pH Gradient Method
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概要
- 論文の詳細を見る
Liposomal irinotecan was prepared by pH gradient loading. The parameters that govern this process, including drug loading time,incubation temperature,buffer composition for hydration, and ΔpH, were studied. The uptake of irinotecan into liposomal systems in response to the magnitude of the pH gradient was examined. The drug uptake was maximum when the magnitude of ΔpH approached 3.7. The effect of the formulation of the liposomes on the stability of the drug delivery system was also studied. Liposomes composed of lipids with a high phase transition temperature, L-α-distearoyl-phophatidyl-choline and hydrogenated soy phosphatidylcholine, were more stable than those composed of lipids with lower phase transition temperatures. Incorporating distearoyl phosphatidylethanolamine-poiy (ethylene glycol)_<2000> into liposomes helped to reduce the size of the liposomes. In addition, the retention of a drug within liposomes was found to be slightly enhanced by including dimyristoylphosphatidylglycerol or dextran sulfate in the liposome formulation.
- 社団法人日本生物工学会の論文
- 2003-04-25
著者
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CHU I-MING
Department of Chemical engineering, National Tsing-Hua University
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Chen S‐c
Advanced Module Technology Division Taiwan Semiconductor Manufacturing Company
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Chu I-ming
Department Of Chemical Engineering National Tsing Hua University
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Chu I-ming
Department Of Chemical Engineering National Tsing Hua University Hsinchit
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Chou Tzung-han
Department Of Cosmetic Science Chia Nan University Of Pharmacy And Science
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Chou Tzung-han
Department Of Chemical Engineering National Tsing Hua University Hsinchit
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CHEN SHIH-CHANG
Department of Chemical Engineering,National Tsing Hua University Hsinchit
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Chou Tzung-Han
Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology
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