Liposomal Delivery System for Taxol

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概要

• 論文の詳細を見る

• Encapsulaton of taxol (paclitaxel) by liposomes provides an environment that enhances the solubility of taxol and avoids side effects caused by Cremophor EL, the emulsifier currently used. In this study, a suitable formula and production method for the liposomal delivery system were investigated. A combination of bath-type sonication and passege through ultrafiltration membranes was found to be the best way to produce liposomes particles of uniform size in the range of 100-200 nm. Phosphatidylcholine and phosphatidylglycerol in a 7 : 3 lipid molar ratio together with 40%, cholesterol, 25% α-tocopherol and 3% taxol (in mol/mol lipids), further resulted in liposomes with himogeneous and stable particle sizes. This taxol delivery method was found to have superior therapeutic effects in tests conducted on mice with transplanted liver tumors in comparison with taxol deliverd in ethanol/Cremophor EL formula.

• 社団法人日本生物工学会の論文
• 1997-01-25

著者

• CHU I-MING

  Department of Chemical engineering, National Tsing-Hua University

• Chu I-ming

  Department Of Chemical Engineering National Tsing Hua University

• SHIEH MENG-FENNG

  Department of Chemical Engineering, National Tsing Hua University

• LEE CHAU-JEN

  Department of Chemical Engineering, National Tsing Hua University

• KAN PEI

  Department of Chemical Engineering, National Tsing Hua University

• HAU DOU-MONG

  Department of Radiation Biology, National Tsing Hua University

• SHIEH JIUNN-JAY

  Deaprtment of Radiation Biology, National Tsing Hua University

• Lee Chau-jen

  Department Of Chemical Engineering National Tsing Hua University

• Kan Pei

  Department Of Chemical Engineering National Tsing Hua University

• Hau Dou-mong

  Department Of Radiation Biology National Tsing Hua University

• Shieh Jiunn-jay

  Deaprtment Of Radiation Biology National Tsing Hua University

• Shieh Meng-fenng

  Department Of Chemical Engineering National Tsing Hua University

• Shieh Meng-Feng

  Department of Chemical Engineering, National Tsing Hua University

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