スズメバチ幼虫分泌アミノ酸溶液(Hornet Larval Salivary Amino Acid Mixture: HLSA)に含有するケト原性および糖原性アミノ酸摂取が運動時代謝応答に及ぼす影響

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Previous studies have suggested that HLSA (consisting of 17 amino acids) supplementation accelerates lipid metabolism and maintains blood glucose during endurance exercise. Purpose: The aim of this study is to examine the influences of the oral ingestion of ketogenic and glucogenic amino acids, those are the characteristic amino acids in HLSA, on metabolic responses during endurance exercise. Methods: Six men performed treadmill-running exercise for 60 min at 50% of maximum oxygen uptake after oral ingestion of (1) 1.5% ketogenic amino acids solution (KetoAA; leucine: tyrosine: lysine), (2) 1.5% glucogenic amino acids solution (GluAA; alanine: glycine: proline) and (3) 1.5% glucose solution (placebo) . Blood samples were collected every 30 min as follows; 30 min before: rest, 0 min: at the start of exercise, 30 min: during exercise, 60 min: end of exercise, 90 min: recovery. Results: There was no difference in blood glucose, blood lactate, plasma catecholamine, oxygen uptake and respiratory exchange ratio (R) among all three groups. Although maintenance of blood glucose was most apparent in KetoAA, R of KetoAA was slightly lower than those of the other groups. At 30 min, serum ketone body concentration was significantly higher in KetoAA than in the other groups (P<0.01). Serum leucine, tyrosine and lysine in KetoAA were significantly higher in comparison with the other groups from 0 to 90 min (P<0.01). Serum isoleucine and valine were significantly lower in KetoAA at 60 min and 90 min (P<0.01). In GluAA, no apparent effect was seen in any of the examined parameters except for serum amino acids. Conclusions: These results suggest that KetoAA supplementation increases the serum ketone body concentration, maintains blood glucose and may promote isoleucine and valine metabolism during endurance exercise. On the contrary, GluAA supplementation does not promote an increase in blood glucose. The metabolic responses of HLSA supplementation may be partly associated with leucine, tyrosine, lysine, isoleucine, and valine.
日本運動生理学会の論文
2002-02-28

スズメバチ幼虫分泌アミノ酸溶液(Hornet Larval Salivary Amino Acid Mixture: HLSA)に含有するケト原性および糖原性アミノ酸摂取が運動時代謝応答に及ぼす影響

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