Increases in Interleukin-6 and Matrix Metalloproteinase-9 in the Infarct-Related Coronary Artery of Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Background To elucidate the involvement of inflammation in coronary artery occlusion, the regional changes in cytokines and matrix metalloproteinases (MMPs) in the infarct-related coronary artery were determined in patients with acute myocardial infarction. Methods and Results Cardiac catheterization was carried out within 24h of the onset of infarction in 36 patients. Blood samples were collected from the infarct-related coronary artery, the ascending aorta and the peripheral vein. Plasma interleukin (IL)-6 concentrations were elevated in all 3 samples. Particularly, the plasma IL-6 concentrations were 14.4pg/ml in the infarct-related coronary artery, a value significantly greater than the respective 8.0pg/ml and 6.5 pg/ml in the ascending aorta and peripheral vein. Plasma IL-6 concentrations in the infarct-related coronary artery had positive correlation with all of the following references measured by intravascular ultrasound: external elastic membrane cross-sectional area (EEM-CSA) (r=0.47, p<0.01), lesion EEM-CSA (r=0.51, p<0.01) and plaque area (r=0.48, p<0.01). MMP-9 was increased regionally in the infarct-related coronary artery, at 11.8ng/ml vs 8.2ng/ml in the ascending aorta (p<0.001). Conclusions The present findings suggest that IL-6 at least is released from the ruptured vulnerable atherosclerotic plaque and that regional activation of macrophages is involved in the occlusive process of coronary artery in acute myocardial infarction.
- 社団法人日本循環器学会の論文
- 2004-04-20
著者
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ISHIKAWA San-e
Department of Medicine, Jichi Medical University Saitama Medical Center
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Ishikawa San-e
Department Of Integrated Medicine 1 Cardiovascular Division Jichi Medical University Saitama Medical
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Ishikawa San-e
自治医科大学附属さいたま医療センター 循環器科
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Ishikawa San-e
自治医科大学 腎臓内科学
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Saito Muneyasu
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
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Yasu Takanori
Department Of Clinical Pharmacology & Therapeutics
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Yasu Takanori
Department Of Clinical Pharmacology & Therapeutics University Of The Ryukyus Graduate School Of
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Funayama Hiroshi
Department of Internal Medicine, Saitama Medical Center, Jichi Medical University
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Kubo Norifumi
Department of Internal Medicine, Saitama Medical Center, Jichi Medical University
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Kawakami M
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
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KATAYAMA Takuji
First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
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Katayama Takuji
Department of Internal Medicine, Omiya Medical Center, Jichi Medical University
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Kawakami Masanobu
Department Of Comprehensive Medicine Jichi Medical University Omiya Medical Center
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Saito Muneyasu
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Kanda Masaru
Department Of Medicine Jichi Medical University Saitama Medical Center
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Ishikawa San-e
Department Of General Internal Medicine Omiya Medical Center Jichi Medical School
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Kubo Norifumi
Cardiovascular Division Jichi Medical University Saitama Medical Center
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Funayama Hiroshi
Cardiovascular Division Jichi Medical University Saitama Medical Center
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Saito Muneyasu
Cardiovascular Division Department Of Integrated Medicine I
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Tada Yuuko
Division Of Cardiology Saitama Medical Center Jichi Medical School
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Katayama Takuji
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
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Kanda M
Department Of Surgical Neurology Jichi Medical School Omiya Medical Center
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Yasu Takanori
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshima University
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ISHIKAWA SAN-E
Department of Endocrinology and Metabolism, Jichi Medical School
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Kubo Norifumi
Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University
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Funayama Hiroshi
Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University
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Katayama Takuji
Department of Hematology, Internal Medicine, Kitasato University School of Medicine, Japan
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KATAYAMA Takuji
Department of Hematology, Internal Medicine, Kitasato University School of Medicine
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