Exercise Training in Patients With Chronic Heart Failure Improves Endothelial Function Predominantly in the Trained Extremities

概要

論文の詳細を見る
The present study investigates whether lower-limb dominant exercise training in patients with chronic heart failure (CHF) improves endothelial function primarily in the trained lower extremities or equally in the upper and lower extremities. Twenty-eight patients with CHF were randomized to the exercise or control group. The exercise group underwent cycle ergometer training for 3 months while controls continued an inactive sedentary lifestyle. Exercise capacity (6-min walk test) and flow-mediated vasodilation in the brachial and posterior tibial arteries were evaluated. After 3 months, walking performance increased only in the exercise group (488±16 to 501±14m [control]; 497±23 to 567±39m [exercise, p<0.05]). The flow-mediated vasodilation in the brachial arteries did not change in either group (4.2±0.5 to 4.5±0.4% [control]; 4.3±0.5 to 4.6±0.4% [exercise]), but that in the posterior tibial arteries increased only in the exercise group (4.1±0.5 to 4.1±0.3% [control]; 3.6±0.3 to 6.4±0.6% [exercise, p<0.01]). Cycle ergometer training improved flow-mediated vasodilation in the trained lower limbs, but not in the untrained upper limbs. Exercise training appears to correct endothelial dysfunction predominantly by a local effect in the trained extremities. (Circ J 2003; 67: 505-510)
社団法人日本循環器学会の論文
2003-05-20