Effects of Pitavastatin on Fasting and Postprandial Endothelial Function and Blood Rheology in Patients With Stable Coronary Artery Disease
スポンサーリンク
概要
- 論文の詳細を見る
Background: Because postprandial hypertriglyceridemia and hyperglycemia may promote atherosclerosis, the present study investigated the effects of a clinical dose of pitavastatin on endothelial function and blood rheology in patients with coronary artery disease (CAD) before and after eating a test meal. Methods and Results: The 16 patients with stable CAD and mild dyslipidemia and 6 age-matched healthy men as controls were recruited. In each group, forearm blood flow (FBF) was measured during postischemic reactive hyperemia and blood samples were taken before and 2 h after the test meal. Urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) was also measured. The patients were started on pitavastatin 2 mg/day. The tests were repeated after 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in CAD patients than in control subjects (P=0.040). Fasting and postprandial FBF during reactive hyperemia significantly improved after pitavastatin treatment (P<0.05 vs baseline data for each phase) associated with reduced urine 8-OHdG, increased plasma adiponectin and improved lipid profile. No significant differences in baseline rheological parameters were seen between controls and CAD patients. Conclusions: Pitavastatin significantly improved fasting and postprandial dyslipidemia and endothelial dysfunction in CAD patients, partly via reducing oxidative stress and increasing plasma adiponectin, although rheological parameters remained unchanged. (Circ J 2009; 73: 1523 - 1530)
- 社団法人 日本循環器学会の論文
- 2009-07-20
著者
-
Murata Seiichiro
Cardiovascular Division Jichi Medical University Saitama Medical Center
-
Ueda Shinichiro
Department Of Clinical Pharmacology & Therapeutics
-
Ueda Shin-ichiro
Department Of Clinical Pharmacology And Therapeutics University Of The Ryukyus Graduate School Of Me
-
Ikeda Nahoko
First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
-
Umemoto Tomio
First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
-
Arao Kenshiro
First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
-
Kawakami Masanobu
First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
-
Momomura Shin-ichi
First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
-
Yasu Takanori
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
-
Ikeda Nahoko
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
-
Ikeda Nahoko
First Department Of Integrated Medicine Omiya Medical Center Jichi Medical University
-
Kakehashi Akihiro
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
-
Umemoto Tomio
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
-
Yasu Takanori
Department Of Clinical Pharmacology & Therapeutics
-
Yasu Takanori
Division Of Cardiovascular Medicine Department Of Integrated Medicine I Jichi Medical University Sai
-
Yasu Takanori
Department Of Clinical Pharmacology & Therapeutics University Of The Ryukyus Graduate School Of
-
Kanda Masaru
Department Of Surgical Neurology Jichi Medical School Omiya Medical Center
-
Kawakami M
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
-
JINBO Sachimi
First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
-
Kawakami Masanobu
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
-
Kanda Masaru
Department Of Medicine Jichi Medical University Saitama Medical Center
-
Jinbo Sachimi
First Department Of Integrated Medicine Saitama Medical Center Jichi Medical University
-
Momomura Shin-ichi
Cardiovascular Division Jichi Medical University Saitama Medical Center
-
Tada Yuuko
Division Of Cardiology Saitama Medical Center Jichi Medical School
-
Yasu Takanori
Division Of Cardiovascular Medicine Department Of Integrated Medicine I Jichi Medical University Sai
-
Tada Yuko
Cardiovascular Division Department Of Medicine Jichi Medical University Saitama Medical Center
-
Kanda M
Department Of Surgical Neurology Jichi Medical School Omiya Medical Center
-
Yasu Takanori
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshima University
-
Ikeda Nahoko
Division Of Cardiovascular Medicine Department Of Integrated Medicine I Jichi Medical University Saitama Medical Center
関連論文
- Effects of Submaximal Exercise on Blood Rheology and Sympathetic Nerve Activity
- PJ-497 Cardiac Resynchronization Therapy Improves not Only Cardiac Function but Endothelial Function in Patients with Chronic Heart Failure(PJ084,CRT (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Effects of Submaximal Exercise on Blood Rheology and Sympathetic Nerve Activity
- Therapeutic Program of Exercise after Heparin with-without Lipo-PGE_1 Administration for Patients with Arteriosclerosis Obliterans(Exercise Training and Cardiac Rehabilitation (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-169 Serum Levels of Pigment Epithelium Derived Factor are Positively Associated with Visceral Adiposity in Japanese Patients with Type 2 Diabetes(PJ029,Diabetes 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulat
- PE-296 Serum Levels of High Mobility Group Box 1 are Associated with Blood Pressure and Renal Function in Elderly Japanese Outpatients(PE050,Diabetes 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-667 Pigment Epithelium-Derived Factor (PEDF) Inhibits Neointima Formation by Suppressing NADPH Oxidase-Mediated Reactive Oxygen Species Generation(Molecular biology, vascular-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-272 Pigment Epithelium-Derived Factor (PEDF) Inhibits Occlusive Thrombus Formation : Possible Participation of Reduced Intraplatelet PEDF Levels in Acute Coronary Syndromes(Thromboembolism/Antithrombotic therapy/Thrombolysis-5, The 71st Annual Scientif
- PE-540 Pigment Epithelium-Derived Fctor (PEDF) Inhibits Injury-induced Brain Edema in Mice(Molecular biology, vascular-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-062 Matrix Metalloproteinase-9 Secretion from Vulnerable Plaque in Patients with Acute Coronary Syndrome : Optical Coherence Tomography Study(OJ11,ACS/AMI (Clinical/Diagnosis) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The
- Long-Term Prognosis of Fulminant Myocarditis Rescued by Percutaneous Cardiopulmonary Support Device
- 5 Free Fatty Acid from Expanded Visceral Fat may Impair Insulin Sensitivity Partly through Activated Renin-angiotensin System in Mononuclear Cells(Key Players of Metabolic Syndrome,Symposium 4 (SY-04) (M),The 73rd Annual Scientific Meeting of The Japanese
- FRS-108 Reversal of Fatty Acid-induced Reactive Oxygen Species (ROS) Production in Obese Rat Endothelium by Hydroxymethylglutaryl-CoA Reductase Inhibition(Progress in Preventive Medicine-2 (H) FRS22,Featured Research Session (English),The 70th Anniversary
- Inhibition of Renin-angiotensin System Restores Free Fatty Acid-induced Endothelial Dysfunction in Humans(Endothelium/NO 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Increased Plasma Angiotensin II Attenuates Vasodilator Effects of Atrial Andbrain Natriuretic Peptides through Angiotensin II Type 1 Receptor(Neurohumoral Factors 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Methodological Validity and Feasibility of the Nitric Oxide Clamp Technique for Nitric Oxide Research in Human Resistant Vessels
- Equivalent Effects of Ca Antagonist-Based and ACE Inhibitor-Based Antihypertensive Therapy on Endothelial Function in Patients with Essential Hypertension : Crossover Trial
- PJ-822 Predictors of Restenosis after Sirolimus Eluting Stent Implantation in the Real World(Coronary revascularization, PCI(26)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-444 Plaque Characterization in Chronic Kidney Patients Analyzed by Virtual Hestology Intravascular Ultrasound(Kidney/Renal circulation(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-234 Enhanced CD40 Ligand Levels are Associated with No Reflow Phenomenon and Left Ventricular Dysfunction in Patients with Acute Myocardial Infarction(Atherosclerosis, clinical(04)(IHD),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of
- Transient Mid-ventricular Ballooning Cardiomyopathy : A New Entity of "Takotsubo" Cardiomyopathy?(Cardiomyopathy, Clinical 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Long Progress and Prognosis of Angina Pectoris in PCI Generation
- Vasospastic Total Occlusion at the Left Main Tract in a Single Coronary Artery
- Effects of Pitavastatin on Fasting and Postprandial Endothelial Function and Blood Rheology in Patients With Stable Coronary Artery Disease
- Diabetes Mellitus as a Predictor of Retinopathy Associated With Acute Myocardial Infarction
- PJ-454 Induction of Endothelial Cell Apoptosis and Monocyte Metalloproteinase-9 Production by C-Reactive Protein(PJ077,Infection/Inflammation/Immunity (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-132 Evaluation of Coronary Intervension by Optical Coherence Tomography in Patients with Acute Coronary Syndrome(PJ022,Coronary Revascularization, PCI (New Devices/New Technology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of
- PJ-113 Effect of Statin Therapy on Plaque Volume and Composition in Patients with Acute Myocardial Infarction : A Virtual Histology Study(PJ019,Atherosclerosis (Clinical/Treatment) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of Th
- Determinants of in-hospital death in left main coronary artery myocardial infarction complicated by cardiogenic shock
- Daily Exercise and Bone Marrow-Derived CD34^+/133^+ Cells After Myocardial Infarction Treated by Bare Metal Stent Implantation
- PJ-471 Polyol Pathway Activation is More Contributed to Impaired Shear Stress-induced Endothelial Nitric Oxide Production in Hyperglycemia Than Oxidative Stress(Diabetes/Obesity/Metabolic syndrome(11)(H),Poster Session(Japanese),The 72nd Annual Scientific
- PJ-197 Increases in Metalloproteinase-8 in patients with acute myocardial infarction(Acute myocardial infarction, clinical (diagnosis/treatment)(09)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-004 Reduction of Neointimal Hyperplasia after Coronary Stenting by Pioglitazone in Nondiabetic Patients with Metabolic Syndrome(Coronary revascularization, PCI(05)(IHD),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- Determinants of In-Hospital Death and Rupture in Patients With a Stanford B Aortic Dissection
- PJ-555 Nateglinide Confers Protection against Apoptosis through Akt-and ERK1/2-Dependent Pathways in Cultured Cardiomyocytes(Cardiovascular pharmacology, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Evidence From Randomized Controlled Trials (RCTs) of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II–Receptor Blockers — Questions Remain Unsolved
- OE-115 Impact of Visceral Fat Obesity on Endothelial Function in Subjects with the Metabolic Syndrome(Diabetes/Obesity/Metabolic syndrome-1 (H) OE20,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
- Endothelium-Dependent and Independent Vasodilatation Are Both Impaired in Conditions Associated with the Metabolic Syndrome
- PE-181 Dihydropyridine Calcium Channel Blockers Inhibit Free Fatty Acid-induced Endothelial Dysfunction, Rheological Disorder and Leukocyte Activation Partially via Anti-oxidant Effect(PE031,Metabolic Syndrome 2 (H),Poster Session (English),The 73rd Annua
- OJ-175 Elevated Free Fatty Acids from Visceral Adipose Tissue Cause Microcirculatory Dysfunction Partly via Local Renin-Angiotensin System in Mononuclear Cells(OJ30,Hypertension, Clinical (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting
- OE-193 Myocardial Perfusion in Takotsubo Cardiomyopathy(OE33,Echo/Doppler (Coronary) (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-530 Clinical feasibility of Non-stress Contrast Echocardiography to Evaluate Coronary Stenosis in Acute Coronary Syndrome(Echo/Doppler(10)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-690 Determinants of In-hospital Death and Rupture in Stanford B Aortic Dissections(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-260 Erythropoietin Protects Cultured Cardiomyocytes from Apoptosis Induced by Tumor Necrosis Factor-α(Cardiovascular pharmacology, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Evaluation of Transmural Myocardial Perfusion by Ultra-Harmonic Myocardial Contrast Echocardiography in Reperfused Acute Myocardial Infarction
- Multi-Detector Computed Tomography for Imaging of Subendocardial Infarction : Prediction of Wall Motion Recovery After Reperfused Anterior Myocardial Infarction
- Intravenous Myocardial Contrast Echocardiography and Multi-Detector Computed Tomography Predict Recovery of Regional Wall Motion in Reperfused Acute Myocardial Infarction
- Rupture of the Anterolateral Papillary Muscle Caused by a Single Diagonal Branch Obstruction
- Comparison of the Role between Paraventricular Nucleus (PVN) and Dorsomedial Hypothalamic Nucleus (DMH) in Cardiovascular Response Evoked from Hypothalamus
- Plaque characterization of non-culprit lesions by virtual histology intravascular ultrasound in diabetic patients : Impact of renal function
- PJ-502 Plasma Placental Growth Factor Level in the Patients with Congestive Heart Failure(Heart failure, clinical-15, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-385 Prompt Changes in the Plaque Composition of a Non-culprit Coronary Artery in Patients with AMI : A Virtual histology study(Intravascular endoscopy/Intravascular ultrasound-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Association of Hyperadiponectinemia With Severity of Ventricular Dysfunction in Congestive Heart Failure
- Close Association of Regional Interleukin-6 Levels in the Infarct-Related Culprit Coronary Artery With Restenosis in Acute Myocardial Infarction
- PJ-200 Association of Hyperadiponectinemia with Severity of Ventricular Dysfunction in Congestive Heart Failure(Heart failure, clinical-11 (M) PJ34,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Societ
- PJ-088 Relation between Lipid Parameters and Coronary Plaque Composition : A Virtual Histology Analysis(Intravascular endoscopy/Intravascular ultrasound-6 (I) PJ15,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- PE-508 Myeloperoxidase May Contribute to the No-reflow Phenomenon in Patients with Acute Myocardial Infarction(Myocardial ischemia-reperfusion, basic/clinical-3 (IHD) PE85,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japa
- PJ-267 Clinical Feasibility of 16-Slice Computed Tomography to Noninvasively Assess Plaque Characterization in Acute Coronary Syndrome : Comparison with Intracoronary Ultrasound Imaging(X-ray/CT/MRI/DSA4 (I) : PJ45)(Poster Session (Japanese))
- PE-185 Assessment of Myocardial Perfusion in Acute Anterior Myocardial Infarction by Contrast Echocardiography : 1.5 Rate Subtraction Imaging vs. Ultra-harmonic Imaging(Echo/Doppler 8 (I) : PE32)(Poster Session (English))
- Impact of acute hyperglycemia during primary stent implantation in patients with ST-elevation myocardial infarction
- PE-287 Long Term Clinical Follow-up after Sirolimus-eluting Stent versus Bare-metal Stent Implantation in Patients with Acute Coronary Syndrome(PE048,ACS/AMI (Clinical/Diagnosis/Pathophysiology) (IHD),Poster Session (English),The 73rd Annual Scientific Me
- PJ-759 Prognostic importance of hyponatremia in patients with acute myocardial infarction(Acute myocardial infarction, clinical(diagnosis / treatment)(12)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- PJ-386 Serial Changes in CD34+/133+ Cell Number before and after Percutaneus Coronary Intervention(Angina pectoris, basic/clinical(04)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Hepatocyte growth factor inhibits production of matrix metalloprotease-9 induced by monocyte-vascular endothelial cell interaction
- Monocyte-vascular endothelial cell interaction inhibits apoptosis of vascular endothelial cells by inducing Bcl-2
- Flow-Mediated Vasodilation as a Diagnostic Modality for Vascular Failure
- Circulating CD34^+/133^+ Progenitor Cells in Patients With Stable Angina Pectoris Undergoing Percutaneous Coronary Intervention
- PE-168 Effects of Low-density Lipoprotein Apheresis and Exercise in Patients with Non-option Peripheral Arterial Disease on Hemodialysis(Exercise test/Cardiac rehabilitation-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-588 Diabetes Mellitus and High Peak Creatine Kinase are Risk Factors of the Retinopathy Associated with Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-4 (IHD) PJ99,Poster Session (Japanese),The 70th Anniversary Annu
- Predictor of Slow Flow/No Reflow during Elective Percutaneous Coronary Intervention in Patients with Angina Pectoris (A Intravascular Ultrasound Study)(Intravascular Endoscopy/Intravascular Ultrasound 3 (I), The 69th Annual Scientific Meeting of the Japan
- Effects of a Distal Protection Device During Primary Stenting in Patients With Acute Anterior Myocardial Infarction
- PJ-492 N-terminal Pro-atrial Natriuretic Peptide after Exercise as a New Marker for Exercise Prescription in Patients with Cardiovascular Diseases(Exercise Test/Cardiac Rehabilitation 6 (IHD) : PJ82)(Poster Session (Japanese))
- PJ-149 HMG CoA Reductase Inhibitor Improves Endothelial Function During Postprandial Hyperlipidemia and Hyperglycemia in Patients with Angina Pectoris(Endothelium/NO 2 (H) : PJ25)(Poster Session (Japanese))
- OE-262 Stress Myocardial Contrast Echocardiography using 1.5 Harmonic Pulse Rate Subtraction Imaging to Assess Myocardial Microcirculation in Patients with Angina Pectoris(Echo/Doppler 12 (I) : OE32)(Oral Presentation (English))
- Impact of Gliclazide on Leukocyte Involvement into Microvessels Subjected to Ischemia/Reperfusion in Streptozotocin-Induced Diabetic Rats
- Exercise after Heparin Administration, A New Therapeutic Program for Patient with Arteriosclerosis Obliterans
- Echocardiographical Demonstration of a Progressively Expanding Left Ventricular Aneurysm Preceded by Endomyocardial Tearing
- Acutely Severe Myocarditis Successfully Treated by Percutaneous Cardiopulmonary Support Applied by a Newly Developed Heparin-Binding Oxygenator and Circuits
- Venous thrombus formation following percutaneous cardiopulmonary support
- PJ-115 Acute Respiratory Distress Syndrome Associated with Acute Aortic Dissection : Its Clinical Features and Early Predictors(Peripheral circulation-8 (H) PJ20,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circ
- Exercise After Heparin Administration : New Therapeutic Program for Patients With Non-Option Arteriosclerosis Obliterans
- Clinical Background and Manifestations of Transient Retinopathy after Acute Myocardial Infarction
- Effect of Reperfusion Therapy on Cardiac Rupture After Myocardial Infarction in Japanese
- Exercise Training in Patients With Chronic Heart Failure Improves Endothelial Function Predominantly in the Trained Extremities
- Regional Interleukin-6 Levels in the Culprit Coronary Artery after Coronary Angioplasty May Predict Restenosis in Acute Myocardial Infarction
- Distal Protection Device Reduces Slow Flow after Stenting in Acute Coronary Syndrome
- Early Invasive Strategy for Acute Myocardial Infarction Improves Long-Term Prognosis in High-Aged Patients
- Up-Regulated Synthesis of Adrenomedullin in Coronary Circulation Immediately after Reperfusion in Patients with Anterior Acute Myocardial Infarction
- Elevated levels of interleukin-6 in infarct-related Coronary Artery in patients with acute myocardial infarction
- PJ-295 Long-Term Clinical Feasibility of Right Atrial Septal pacing(Arrhythmia, therapy-20, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-375 Aldose Reductase Inhibitor Improves the Deterioration of Shear Induced Nitric Oxide Production by High Glucose(Endothelium-3 (H) PE63,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Osteopontin is Required for Monocyte-induced Inhibition of Endothelial Cell Apoptosis(Apoptosis/Necrosis/Regeneration 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-220 Feature of Plaque Components in the Angiographic No-reflow Cases(Intravascular endoscopy/Intravascular ultrasound-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Early Development of Hyponatremia Implicates Short- and Long-Term Outcomes in ST-Elevation Acute Myocardial Infarction
- New Approaches to Blockade of the Renin-Angiotensin-Aldosterone System : Evidence From Randomized Controlled Trials (RCTs) of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II-Receptor Blockers-Questions Remain Unsolved
- PE-402 Monocyte-Endothelial Cell Interaction Inhibits Endothelial Cell Apoptosis via an ERK1/2-Dependent Pathway(Apoptosis/Necrosis/Regeneration 2 (M) : PE68)(Poster Session (English))
- Optimal Combination of Effective ANtihypertensives (OCEAN) study : a prospective, randomized, open-label, blinded endpoint trial-rationale, design and results of a pilot study in Japan
- Congestive heart failure in the elderly : Comparison between reduced ejection fraction and preserved ejection fraction
- A Multicenter Study Design to Assess the Clinical Usefulness of Semi-Automatic Measurement of Flow-Mediated Vasodilatation of the Brachial Artery
- Whole Blood Passage Time : What Does It Mean? : Reply