Effect of an Endothelin Receptor Antagonist and an Angiotensin Converting Enzyme Inhibitor on Metabolism and Contraction in the Ischemic and Reperfused Rabbit Heart
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概要
- 論文の詳細を見る
The effect of an endothelin(ET)A/ETB receptor antagonist, TAK-044, and/or an angiotensin converting enzyme(ACE)inhibitor, temocaprilat, on myocardial metabolism and contraction during ischemia and reperfusion was examined by phosphorus 31-nuclear magnetic resonance(^<31>P-NMR)in Langendorff rabbit hearts. After normothermic 15 min global ischemia, 60 min of postischemic reperfusion was carried out. TAK-044 and/or temocaprilat was administered from 40 min prior to the global ischemia. Adenosine triphosphate(ATP), creatine phosphate, inorganic phosphate, pH, left ventricular systolic developed pressure(LVDev.P), left ventricular end-diastolic pressure(LVEDP)and coronary flow were measured. Twenty-eight hearts were divided into 4 experimental groups consisted of seven hearts each:Group I consisted of controls, Group II was perfused with TAK-044(10^<-6>mol/L), Group III was perfused with temocaprilat(10^<-6>mol/L), and Group IV was perfused with TAK-044(10^<-6>mol/L)in combination with temocaprilat(10^<-6>mol/L). Group II showed a more early recovery of ATP during postichemic reperfusion(82±3%)compared with Group I(71±3%). Group III showed a significant inhibition of the decrease in ATP during global ischemia(54±3%)compared with Group I(45±3%). Group IV also showed a significant marked inhibition of the decrease in ATP during global ischemia(59±5%)and a more significant improvement on recovery of ATP during postischemic reperfusion(86±3%)compared with the other 3 groups. There were no differences in LVDev. P, LVEDP and coronary flow among these groups. In conclusion, TAK-044 in combination with temocaprilat had a significant potentiation on myocardial metabolism during both ischemia and reperfusion.
- 社団法人日本循環器学会の論文
- 1999-09-20
著者
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ISHIKAWA Kinji
First Dept. of Inter. Med Tohoku Univ. School of Med.
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Kawabata Hitoshi
First Department of Internal Medicine, Kinki University School of Medicine
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Ishikawa Kinji
First Department Of Internal Medicine Kinki University School Of Medicine
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RYOMOTO Teruhiko
First Department of Internal Medicine, Kinki University School of Medicine
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Ryomoto Teruhiko
First Department Of Internal Medicine Kinki University School Of Medicine
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Kawabata Hitoshi
First Department Of Internal Medicine Kinki University School Of Medicine
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