<Originals>The Efficacy of Oxygen Inhalation on Acutely-Induced Ischemic Myocardium in Dogs

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The efficacy of arterial hyperoxia in ameliorating myocardial ischemia was studied in 22 open-chest mongrel dogs. The left anterior descending coronary artery was partially occluded in order to induce myocardial ischemia. The coronary venous blood draining from the ischemic myocardium was sampled for purposes of analysis. Respiratory gas was switched from room air to 40% oxygen/60% nitrogen and then to 100% oxygen. To exclude time course changes, the respiratory gas was changed from 100% oxygen back to 40% oxygen, and then back to air. Each time, heart rate, aortic pressure, aortic flow, myocardial contractile force and epicardial electrocardiograms were recorded and coronary venous blood samples were taken. Heart rate and aortic pressure remained stable throughout the study. Arterial blood pO_2 during air, 40% oxygen, and 100% oxygen were 80.7±2.5 (M±SE), 141.4±5.5 and 4l2.4±22.4 mmHg, respectively. Changing the respiratory gas from air to 40% oxygen produced a significant elevation in coronary venous oxygen saturation (from 35.8±4.2 to 41.1±4.0), a decrease in myocardial oxygen extraction (from 63.6±5.1 to 60.5±4.9%) and lactate shifted from production to utilization (from -0.9±12.3 to 5.0±12.2%). These changes were even more marked when 100% oxygen was used ; they were characterized by a further increase in coronary venous oxygen saturation (to 50.6±4.2%), a decrease in myocardical oxygen extraction (to 53.8± 5.3%) and an improvement in lactate utilization (to 7.8±13.5%). These changes were all reproduced when 100% oxygen was changed back to 40% oxygen, and again when 40% oxygen was changed back to air. This study indicates that 40% oxygen breathing is effective and that 100% oxygen breathing is even more effective in ameliorating acutely induced ischemic changes of the myocardium.
近畿大学の論文
1983-06-28

<Originals>The Efficacy of Oxygen Inhalation on Acutely-Induced Ischemic Myocardium in Dogs

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