大動脈の栄養血管の分布に関する新知見とそのLeakage現象について(第1報) : 浮腫性動脈反応に関する研究続報

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Many investigators failed to demonstrate vasa vasorum in the inner third of media in aortic wall with routine histological techniques and it had been believed that the inner third of media may be an avascular area and the nourishment of this area may mainly be provided by the blood running through the aortic lumen. Recently, the introduction of microangiographic technique enabled the study of microcirculation in the vessel wall instead of routine histological technique. J. A. CLARKE, using an X-ray microscopic technique, demonstrated vasa vasorum of human thoracic aorta, revealing the patterns of distribution to the inner third of media just beneath the internal elastic lamina. The purpose of this paper is to describe a finding on the patterns and distributions of vasa vasorum in the aortic wall of dog. Materials and Methods Twelve healthy male dogs weighing 8.5 to 1 3.5kg anaesthetized with sodium pentobarbiturate (5 w/v% 10ml. i. v.) were used. Before the sampling of aortic specimen sodium heparin (500unit/kg) was injected intravenously. The abdomen was opened, the jejunum and ileum were retreated out of the way, and the vena cava inferior and the abdominal aorta were carefully isolated from the surrounding tissues. The both vessels were ligated at the level L_2 to L_4, and each was proximally cannulated with polyethylene tube. All blood in the area under the study was removed by a through flushing with Ringer's solution containing heparin (200 units/ml) at 37'C. Fifty per cent Micropaque solution was injected under manual pressure into the aortic tube in a dose of 300ml at first and then into the venous tube in a dose of 200 ml. Five minutes later, the chest was opened and the aorta was extirpated quickly with the heart. The aorta was isolated and aortic lumen was washed with running water for 3 minutes. A 10 per cent neutral buffered formalin solution was used for the fixation of the material for 48 hours or more. After flxation, the aorta was made into cross or longitudinal section of 0.5 mm to Imm thick, and examined by X-ray microscope. A model of SOFTEX was used as an X-ray source. Exposure time varied 20 to 30 minutes depending on the thickness of specimen, at 7kV at 3mA.
社団法人日本循環器学会の論文
1967-02-20

大動脈の栄養血管の分布に関する新知見とそのLeakage現象について(第1報) : 浮腫性動脈反応に関する研究続報

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