HUMAN SUPEROXIDE DISMUTASE FAILED TO LIMIT THE SIZE OF MYOCARDIAL INFARCT AFTER 20-, 30-, OR 60-MINUTE ISCHEMIA AND 72-HOUR REPERFUSION IN THE RABBIT
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概要
- 論文の詳細を見る
The effect of superoxide dismutase (SOD) on the size of the myocardial infarct resulting from various durations of ischemia and a 72-hour reperfusion was examined in the rabbit. A coronary branch of the circumflex artery was occluded for 20, 30, or 60 min and then reperfused. Seventy-two hours after the coronary occlusion, the infarct size and the size of the area at risk (viscular bed of occluded coronary artery) were determined by histology (hema-toxylin-eosin and Mallory's staining) and by fluorescent particles, respectively. Human SOD (45,000 units/kg) was injected intravenously as a bolus in SOD-treated rabbits, while only saline was administered to control rabbits. The percentage of the area at risk which actually infarcted (%I/AAR) was 25.5±12.9% (mean±S.D.) in the 20-min ischemia control group (n=9), 19.7±10.2% in the 20-min ischemia SOD group (n=9), 41.0±6.3% in the 30-min ischemia SOD group (n=9), 74.2±13.8% in the 60-min ischemia control group (n=9), and 76.6±8.2% in the 60-min ischemia SOD group (n=7). The %I/AAR was not significantly different between the control and SOD groups for any duration of ischemia. Heart rate, blood pressure, and the size of area at risk were comparable in all six groups. These findings suggested that oxygen-free radicals produced during initial moments of reperfusion were unlikely to contribute to myocardial necrosis regardless of the duration of ischemia in the rabbit.
- 社団法人日本循環器学会の論文
- 1989-07-20
著者
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Iimura Osamu
The Second Department Of Internal Medicine Sapporo Medical College
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Miura Tetsuji
The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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Miura Tetsuji
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Miura Tetsuji
The Second Department Of Internal Medicine Sapporo Medical College
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Ogawa Shinsaku
The Second Department of Internal Medicine, Sapporo Medical College
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OOIWA HITOSHI
The Second Department of Internal Medicine, Sapporo Medical College
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SHIZUKUDA YUKITAKA
The Second Department of Internal Medicine, Sapporo Medical College
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ADACHI TAKEO
The Second Department of Internal Medicine, Sapporo Medical College
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NOTO TETSUYA
The Second Department of Internal Medicine, Sapporo Medical College
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Iimura Osamu
The Second Department Of Internal Medicine Sappolo Medical College
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Noto Tetsuya
The Second Department Of Internal Medicine Sapporo Medical College
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Adachi Takeo
The Second Department Of Internal Medicine Sapporo Medical College
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Ooiwa Hitoshi
The Second Department Of Internal Medicine Sapporo Medical College
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Ogawa Shinsaku
The Second Department Of Internal Medicine Sapporo Medical College
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Shizukuda Yukitaka
The Second Department Of Internal Medicine Sapporo Medical College
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IIMURA OSAMU
The Second Department of Internal Mdicine, Sapporo Medical College
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