INHIBITION OF THROMBOXANE A2 SYNTHETASE FAILED TO LIMIT MYOCARDIAL INFARCT SIZE IN A RABBIT ISCHEMIA-REPERFUSION MODEL
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概要
- 論文の詳細を見る
The role of thromboxane A2 (TXA2) in myocardial necrosis during coronary occlusion and reperfusion was investigated by using a new long-acting TXA2 synthetase inhibitor. DP1904. A rabbit coronary branch was occluded for 30 min and then reperfused for 72h. Infarct size and area at risk were determined histologically and by fluorescent particles, respectively, for 4 groups; a saline receiving control group (C group), a DP1904 treated group (DP group), a heparin treated group (H group), and a DP1904 plus heparin treated group (DP-H group). The H group and DP-H group were included to examine the influence of heparinization on the effect of DP1904. In the DP and DP-H groups. 10mg/kg of DP1904 was injected i.v. 2h before coronary occlusion, as well as 24 and 48h after reperfusion. This dose of DP1904 (10mg/kg i.v.) was able to inhibit serum thromboxane B2 formation ex vivo to 1.1% of the control level 2h after its administration, and to 39.5% at 24h, in the rabbit (n=5). The H and DP-H groups received 1000 units of heparin i.v. 3 min prior to coronary occlusion. The size of the area at risk, heart rate, blood pressure, and rate-pressure products were comparable between the 4 groups. Mortality was not significantly different in any group. Myocardial infarct size as the percentage of area at risk was 43.6~3.9% in C group (n=10), 41.1±4.4% in DP group (n=9), 47.8±3.0% in H group (n= 13), and 44.7±4.0% in DP-H group (n=10), which were not significantly different. These findings suggest that TXA2 does not contribute directly to myocardial necrosis during coronary occlusion and reperfusion in the rabbit.
- 社団法人日本循環器学会の論文
- 1991-02-20
著者
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Shimamoto Kazuaki
Second Department Of Medicine Sapporo Medical University School Of Medicine
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Iimura Osamu
The Second Department Of Internal Medicine Sapporo Medical College
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SHIMAMOTO KAZUAKI
The Second Department of Internal Medicine, Sapporo Medical College
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Shimamoto Kazuaki
Second Department Of Internal Medicine Sapporo Medical University
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Miura Tetsuji
The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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Tsuchida Akihito
The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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OGAWA TAKASHI
The Second Department of Internal Medicine, Sapporo Medical College
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IWAMOTO TOSHIHIRO
The Second Department of Internal Medicine, Sapporo Medical College
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Iwamoto Toshihiro
The Second Department Of Internal Medicine Sapporo Medical College
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Miura Tetsuji
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Miura Tetsuji
Second Department Of Internal Medicine Sapporo Medical University
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Miura Tetsuji
The Second Department Of Internal Medicine Sapporo Medical College
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Iimura Osamu
The Second Department Of Internal Medicine Sappolo Medical College
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Tsuchida Akihito
Second Department Of Internal Medicine Sapporo Medical University
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Tsuchida Akihito
The Second Department Of Internal Medicine Sapporo Medical College
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Miura Tetsuji
Second Department Of Medicine Sapporo Medical University School Of Medicine
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Shimamoto Kazuaki
The Seceond Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Ogawa Takashi
The Second Department Of Internal Medicine Sapporo Medical College
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IIMURA OSAMU
The Second Department of Internal Mdicine, Sapporo Medical College
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