STUDY ON THE ATHEROSCLEROSIS MECHANISM IN CHRONIC HEMODIALYSIS

スポンサーリンク

概要

• 論文の詳細を見る

• In order to clarify whether hemodialysis treatment accelerates atherosclerosis, forty-two patients undergoing chronic hemodialysis were investigated. Because it is non-invasive and repeatable, aortic calcification on chest-XP was used as an index of atherosclerosis. No patients had evidence of calcified atherosclerosis at the start of hemodialysis therapy. The patients were divided into three groups according to vascular changes. Group 1 (20 patients) showed no calcification during the observation period. Group 2 (11 patients) had mild or moderate aortic calcification (thin linear aortic calcification). In group 3 (11 patients), massive and severe calcification was accelerated by hemodialysis. 18 parameters which might be considered to promote atherosclerosis were evaluated in each group. The age in group 3 was 53.8±10.4 (mean±standard deviation) years, which was older than the 42.1±12.6 year age in group 1 (p<0.025). duration of dialysis in group 3 was 121.9±30.5 months, which was significantly longer than the 82.031.0 months in group 2 (p<0.01) and the 77.355.3 months in group 1 (p<0.025). serum HDL-cholesterol levels in groups 2 (23.04.5 mg/dl) and 3 (20.96.6 mg/dl) were significantly lower than the 28.68.3 mg/dl in group 1, (p<0.025 and p<0.05, respectively). Serum parathormone-C level in group 3 was 14.78.6 ng/ml, which was significantly higher than the 6.16.0 ng/ml level in group 1 (p<0.01) and the 5.07.8 ng/ml level in group 2 (p<0.025). In discriminant analysis, age, duration of dialysis, hematocrit, serum HDL-cholesterol, parathormone-C, and alkaline phosphatase level were the independent factors used to distinguish the three groups. These findings suggest that 1) aging is a basal factor in the promotion of atherosclerosis, 2) hypo-HDL chlosterolemia is a major factor in the early phase of atherosclerosis, 3) hyperparathyroidism could have an important role in the late phase of atherosclerosis, 4) dialysis itself might promote atherosclerosis directly, and 5) blood pressure level is not major factor for atherosclerosis over a long observation period, at least in our study.

• 社団法人日本循環器学会の論文
• 1987-06-20

著者

• Iimura Osamu

  The Second Department Of Internal Medicine Sapporo Medical College

• Kudoh Yasuo

  The Second Department Of Internal Medicine Sapporo Medical College

• Iimura Osamu

  The Second Department Of Internal Medicine Sappolo Medical College

• IIMURA OSAMU

  The Second Department of Internal Mdicine, Sapporo Medical College

関連論文

• FRAGMENTATION HEMOLYSIS IN A PATIENT WITH HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY AND MITRAL VALVE PROLAPSE
• THE INHIBITORY EFFECT OF NIFEDIPINE ON CARDIAC FUNCTION AND NORADRENALINE RELEASE DURING CARDIAC SYMPATHETIC NERVE STIMULATION : Cardiovascular Drugs (II) : V : 48 Annual Scientific Meeting, Japanese Circulation Society
• THE SIGNIFICANCE OF RENAL CLEARANCE OF NORADRENALINE IN PLASMA NORADRENALINE CONCENTRATION OF ELDER PATIENTS WITH ESSENTIAL HYPERTENSION : Hypertension(I) : I : 48 Annual Scientific Meeting, Japanese Circulation Society
• Plasma Noradrenaline Concentration and Pressor Response to Infused Noradrenaline in Patients with Borderline Hypertension, and Mild or Moderate Essential Hypertension : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES
• THE ROLE OF L-CARNITINE IN THE PATHOGENESIS OF CARDIOMEGALY IN PATIENTS WITH CHRONIC HEMODIALYSIS
• PLASMA ANGIOTENSIN II LEVELS IN ESSENTIAL AND SECONDARY HYPERTENSIVES : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• INHIBITION OF THROMBOXANE A2 SYNTHETASE FAILED TO LIMIT MYOCARDIAL INFARCT SIZE IN A RABBIT ISCHEMIA-REPERFUSION MODEL
• EFFECTS OF INDOMETHACIN ON BLOOD PRESSURE AND RENAL SODIUM METABOLISM IN ESSENTIAL HYPERTENSION : WITH SPECIAL REFERENCE TO PLASMA RENIN ACTIVITY : Hypertension(I) : I : 48 Annual Scientific Meeting, Japanese Circulation Society
• THE ROLE OF Na^+-k^+ ATPase INHIBITOR IN PRESSOR RESPONSE TO INFUSED NORADRENALINE IN NORMOTENSIVE SUBJECTS : Sympathetic Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Intracranial Pheochromocytoma : A Case of Noradrenaline-Secreting Glomus Jugulare Tumor
• -25- EFFECT OF CORONARY COLLATERAL FLOW ON THE OCCURRENCE OF SERIOUS VENTRICULAR ARRHYTHMIAS DURING EARLY PHASE OF ACUTE MYOCARDIAL ISCHEMIA : CORRELATION WITH CARDIAC METABOLISM AND HEMODYNAMICS : Coronary Circulation : FREE COMMUNICATIONS(I) : PROCEEDIN
• THE EFFECT OF INOTROPIC DOSE OF DOBUTAMINE DURING REPERFUSION ON MYOCARDIAL INFARCT SIZE
• HUMAN SUPEROXIDE DISMUTASE FAILED TO LIMIT THE SIZE OF MYOCARDIAL INFARCT AFTER 20-, 30-, OR 60-MINUTE ISCHEMIA AND 72-HOUR REPERFUSION IN THE RABBIT
• -0170-IS THERE AUGUMENTATION OF PRESSOR RESPONSE TO INFUSED NORADRENALINE RELATED TO NA, K ATPASE INHIBITOR IN THE PREHYPERTENSIVE STAGE OF ESSENTIAL HYPERTERNSION?
• THE RELATIONSHIP BETWEEN THE SEVERITY AND THE SITE OF MITRAL VALVE PROLAPSE : Valvular Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
• MORPHOLOGICAL ASSESSMENT OF LEFT VENTRICULAR WALL AND VENTRICULAR ANEURYSM BY THALLIUM-201 MYOCARDIAL EMISSION COMPUTED TOMOGRAPHY
• THE ROLE OF THE RENAL KALLIKREIN-KININ-KININASE SYSTEM IN ESSENTIAL HYPERTENSION AND PRIMARY ALDOSTERONISM : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
• THE ASSESSMENT OF SERIAL CHANGES OF TRANSMITRALFLOW DYNAMICS AFTER PTCA BY PULSED DOPPLER ECHOCARDIOGRAPHY AND ITS CORRELATION TO RESTENOSIS
• MASSIVE MYOCARDIAL CALCIFICATION OF RIGHT AND LEFT VENTRICLES FOLLOWING ACUTE MYOCARDITIS COMPLICATED WITH RHABDOMYOLYSIS-INDUCED ACUTE RENAL FAILURE
• A CASE OF CONGENITAL LEFT VENTRICULAR DIVERTICULUM WITH PULMONARY STENOSIS AND ITS SCINTIGRAPHIC CHARACTERISTICS
• The Role of the Renal Kallikrein-kinin System in Sodium Metabolism in Normal and Low Renin Essential Hypertension : The 12th Conference on the Pathogenesis of Hypertension
• A Very Sensitive Direct Radioimmunoassay System for Plasma Angiotensin II and its Clinical Application in Various Hypertensive Diseases : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• -P98-KININASE ACTIVITIES IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR) AORTA : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• The Pathophysiological Role of Renal Dopaminergic Activity in Patients with Essential Hypertension
• The Pathophysiological Role of Blood Ionized Calcium in Essential Hypertension
• Sympathetic Nerve Activity, Plasma Renin Activity and Water-Sodium Balance in Obese Patients with Essential Hypertension : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• EFFECT OF NORADRENALINE INFUSION ON RENAL SODIUM EXCRETION IN NORMOTENSIVE SUBJECTS AND PATIENTS WITH MILD AND MODERATE ESSENTIAL HYPERTENSION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• Interrelationship between the Pathophysiology and Antihypertensive Treatment in Benign Essential Hypertension : Pathophysiology of Hypertension and its Relation to the Choice of Antihypertensive Treatment
• STUDIES ON THE EXPERIMENTAL CORONARY INSUFFICIENCY (XX) : EFFECT OF HYPERLIPIDEMIA ON THE MYOCARDIAL ISCHEMIA BY SYMPATHETIC NERVE STIMULATION : Ichemic Heart Disease (III) : 46th Annual Scientific Meeting, Japanese Circulation Society
• Effects of Hyperinsulinemia under the Euglycemic Condition on Calcium and Phosphate Metabolism in Non-Obese Normotensive Subjects
• THE DUAL EFFECTS OF HEMODIALYSIS ON CARDIAC FUNCTION ASSESSED BY PULSED DOPPLER ECHOCARDIOGRAPHY
• Insulin Resistance and Hypertension in Japanese
• STUDY ON THE ATHEROSCLEROSIS MECHANISM IN CHRONIC HEMODIALYSIS
• -228-STUDIES ON SEASONAL CHANGES OF BLOOD PRESSURE IN THE COLD CIRCUMSTANCES
• BENIGN VENTRICULAR TACHYCARDIA IN SYSTEMIC SARCOIDOSIS : A Case of False Tendon
• -537- IS ATHEROSCLEROSIS ACCELERATED BY CHRONIC HEMODIALYSIS?
• SLOW CONTINUOUS HEMODIALYSIS : New Therapy for Acute Renal Failure in Critically III Patients : Part 1. Theoretical Consideration and New Technique
• TUBERCULOSIS ON REGULAR HEMODIALYSIS : A Case of Pericardial Tamponade
• Excretion of Human Urinary Kallikrein Quantity Measured by a Direct Radioimmunoassay of Human Urinary Kallikrein in Patients with Essential Hypertension and Secondary Hypertensive Diseases : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• EFFECT OF SALINE INFUSION ON THE RENAL KALLIKREIN-KININ SYSTEM, PROSTAGLANDINS AND SODIUM METABOLISM IN ESSENTIAL HYPERTENSION : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
• EFFECT OF DOPAMINE INFUSION ON THE RENAL KALLIKREIN-KININ SYSTEM AND RENAL SODIUM METABOLISM IN ESSENTIAL HYPERTENSION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• -P126-THE ROLE OF THE VASCULAR VASODILATORY PROSTAGLANDIN ON THE ANTIHYPERTENSIVE MECHANISM OF β-ADRENERGIC RECEPTOR ANTAGONIST PROPRANOLOL : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCU
• SLOW CONTINUOUS HEMODIALYSIS : New Therapy For Acute Renal Failure in Critically III Patients : Part 2. Animal Experiments and Clinical Implication
• THE PATHOPHYSIOLOGICAL ROLE AND DYNAMICS OF RENAL DOPAMINE, KALLIKREINKININ AND PROSTAGLANDIN SYSTEMS IN ESSENTIAL HYPERTENSION : Hypertension (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SO
• URINARY EXCRETIONS OF PREKALLIKREIN IN VARIOUS HYPERTENSIVE DISEASES : Hypertension(I) : I : 48 Annual Scientific Meeting, Japanese Circulation Society
• An Improved Method for the Determination of Human Blood Kinin Levels by Sensitive Kinin Radioimmunoassay
• Plasma Antidiuretic Hormone Levles in Patients with Normal and Low Renin Essential Hypertension, and Secondary Hypertension
• Hemodynamic and Natriuretic Responses to Intravenous Infusion of Dopamine in Patients with Essential Hypertension : THE 11th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Bartter's Syndrome with Gouty Arthritis.
• Hypocalcemic Cardiomyopathy in a Patient with Idiopathic Hypoparathyroidism.

もっと見る 閉じる

スポンサーリンク