Excretion of Human Urinary Kallikrein Quantity Measured by a Direct Radioimmunoassay of Human Urinary Kallikrein in Patients with Essential Hypertension and Secondary Hypertensive Diseases : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

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概要

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• Recently, we established a very sensitive, specific and simple direct radio-immunoassay method for human urinary kallikrein. In this study, in order to clarify whether or not the low or high excretion rate of urinary kallikrein activity in patients with essential hypertension, primary aldosteronism, pheo-chromocytoma and Bartter's syndrome is caused by changes in enzyme quantity, urinary kallikrein excretion was measured with this direct radio-immunoassay method in normal subjects and in patients with these diseases. Urinary kallikrein excretion measured as enzyme quantity was significantly lower in patients with essential hypertension, and higher in patients with primary aldosteronism and Bartter's syndrome. These results are consistent with other previously reported data and our data measured by means of esterase assay or kininogenase assay. The results also suggest that lowered or elevated excretion of urinary kallikrein activity in these diseases is caused, in part at least, by the lowered or elevated excretion of enzyme quantity.

• 社団法人日本循環器学会の論文
• 1981-09-20

著者

• Takahashi Nobuki

  Department Of Clinical Studies And Genetics Radiation Effects Research Foundation

• Iimura Osamu

  The Second Department Of Internal Medicine Sapporo Medical College

• SHIMAMOTO KAZUAKI

  The Second Department of Internal Medicine, Sapporo Medical College

• Nakahashi Yasuyuki

  The Second Department of Internal Medicine, Sapporo Medical College

• Ura Nobuyuki

  The Second Department of Internal Medicine, Sapporo Medical University School of Medicine

• Nakao Takashi

  The Second Department of Internal Medicine, Sapporo Medical College

• Tahara Nobuhiro

  Department Of The Third Internal Medicine Kurume University School Of Medicine

• Iimura Osamu

  The Second Department Of Internal Medicine Sappolo Medical College

• TANAKA SHIGEMICHI

  The Second Department of Internal Medicine,Sapporo Medical College

• CHAO Julie

  Department of Biochemistry and Molecular Biology, Medical University of South Carolina

• Margolius Harry

  Department of Pharmacology and Medicine, Medical University of South Carolina

• Tanaka Shigemichi

  The Second Department Of Internal Medicine Sapporo Medical College

• Nakahashi Yasuyuki

  The Second Department Of Internal Medicine Sapporo Medical College

• Chao Julie

  Department Of Biochemistry And Molecular Biology Medical University Of South Carolina

• Chao Julie

  Department Of Pharmacology Medical University Of South Carolina

• Shimamoto Kazuaki

  The Seceond Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Takahashi Nobuyuki

  Radiation Effects Research Foundation Hiroshima

• OGASAWARA AKIO

  The Second Department of Internal Medicine, Sapporo Medical College

• Ogasawara Akio

  The Second Department Of Internal Medicine Sapporo Medical College

• Margolius Harry

  Department Of Pharmacology And Medicine Medical University Of South Carolina

• IIMURA OSAMU

  The Second Department of Internal Mdicine, Sapporo Medical College

• NAKAHASHI YASUYUKI

  The Second Department of Internal Mdicine, Sapporo Medical College

• TANAKA SHIGEMICHI

  The Second Department of Internal Mdicine, Sapporo Medical College

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