MEASUREMENT OF URINARY KALLIKREIN ACTIVITY BY KININ RADIOIMMUNOASSAY

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概要

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• We have established a simplified assay system for the measurement of urinary kallikrein activity by utilizing the sensitive and specific radioimmunoassay system of kinins previously reported from our laboratory. Kinins were generated by incubating urine samples (50μl) with kininogen (1500 ng) in the presence of kininase inhibitors, and the generated kinins were measured by radioimmunoassay. Since the cross reactivity of kininogen in the kinin radioimmunoassay system was not recognized at dose up to 1.0 μg, the amount of untreated kininogen in the radioimmunoassayed samples did not interfere with the measurement of kinins. This eliminated the necessity for a kininogen extraction procedure. A good linear correlation (r=0.939, p<0.001) was observed between the urinary kallikrein activity determined by this assay system (kininogenase activity) and that by esterolytic activity. Urinary kallikrein activity was 3.3 ± 0.9 μg/min/24hour urine (mean ± SEM), 1.4 ± 0.4 μg/min/24hour urine and 0.25 ± 0.06 μg/min/24hour urine in 6 normal subjects, 7 patients with non-complicated essential hypertension and 4 patients with chronic renal failure, respectively. Thus, urinary kallikrein activity was significantly lower in the patients with essential hypertension (p<0.05) and the patients with chronic renal failure (p <0.01) than the normal subjects.

• 社団法人日本循環器学会の論文
• 1979-04-20

著者

• Shimamoto Kazuaki

  Second Department of Internal Medicine, Sapporo Medical University School of Medicine

• Shimamoto Kazuaki

  手稲渓仁会病院 総合内科

• Takahashi Nobuki

  Department Of Clinical Studies And Genetics Radiation Effects Research Foundation

• Ando Toshiaki

  The Second Department of Internal Medicine, Sapporo Medical College

• Nakahashi Yasuyuki

  The Second Department of Internal Medicine, Sapporo Medical College

• Ando Toshiaki

  The Second Department Of Internal Medicine Sapporo Medical College

• Miyahara Mitsuo

  The Second Department Of Internal Medicine Sapporo Medical College

• MIYAHARA MITSUO

  Second Department of Internal Medicine, Sapporo Medical College

• TANAKA SHIGEMICHI

  Second Department of Internal Medicine, Sapporo Medical College

• NAKAO TAKASHI

  Second Department of Internal Medicine, Sapporo Medical College

• ANDO TOSHIAKI

  Second Department of Internal Medicine, Sapporo Medical College

• NAKAHASHI YASUYUKI

  Second Department of Internal Medicine, Sapporo Medical College

• SAKUMA MAKI

  Sakuma Iin Clinic

• Shimamoto Kazuaki

  The 2nd Department Of Internal Medicine Sapporo Medical University School Of Medicine

• Tanaka Shigemichi

  The Second Department Of Internal Medicine Sapporo Medical College

• Nakahashi Yasuyuki

  The Second Department Of Internal Medicine Sapporo Medical College

• Shimamoto Kazuaki

  Second Department Of Internal Medicine (cardiovascular Medicine) Sapporo Medical University School O

• Mori Masaki

  Division Of Gene Therapy Science Osaka University

• Takahashi Nobuyuki

  Radiation Effects Research Foundation Hiroshima

• Ando Toshilaki

  Second Department Of Internal Medicine Sapporo Medical College Sapporo

• Miyahara Mitsuo

  Second Department Of Internal Medicine Sapporo Medical College

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