Body Fluid Balance and Fractional Excretions of Sodium, Inorganic Phosphorus, Potassium and Free Water in Low Renin Essential Hypertension : VIII CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
スポンサーリンク
概要
- 論文の詳細を見る
Plasma volume (PV), extracellular fluid volume (ECFV) and total exchangeable sodium (Nae) were measured by the dilution methods of ^<131>RISA and ^<22>NaCl in the patients with low-(LRH), normal-(NRH) and high-renin essential hypertension (HRH). In addition, fractional excretion of sodium (FENa) and inorganic phosphorus (FEP) and free water (FEW), urinary Na/K ratio after oral water ingestion of 400 ml/m^2 body surface area, and fractional potassium excretion (FEK) after intravenous injection of 80 ml of 10% sodium thiosulfate, estimated by clearance method, were compared between LRH and NRH. PV, ECFV and Nae, which inversely correlated with logarithm of supine plasma renin activity (log PRA), were significantly higher in LRH than each of NRH and of HRH. FENa and FEP, which are assumed to reflect the renal tubular and proximal tubular sodium reabsorption, were positively correlated with age, severity of hypertension (VA score), mean arterial pressure (MAP) and correlated inversely with endogenous creatinine clearance (Ccr). FENa was also correlated positively with log PRA and negatively with ECFV and Nae in the whole patients with essential hypertension. Twenty-four hour urinary kinins excretion and plasma levels of antidiuretic hormone (ADH) measured by radio immunoassay were compared between LRH and NRH. LRH had significantly lower FENa and FEP than age-, MAP- and Ccr-matched NRH and lower urinary excretion of kinins than age-matched NRH. The mean values of these variables in LRH are almost similar to those in normotensive subjects. Plasma ADH levels and FEW were significantly lower and tended to be lower than those in NRH, respectively. Urinary Na/K ratio and FEK which may reflect the mineralocorticoid action on the renal tubule were not significantly different among these three renin sub-groups.
- 社団法人日本循環器学会の論文
- 1979-10-20
著者
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KUMAGAI Hiroo
National Defense Medical College
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Kikuchi Kenjiro
The 2nd Department Of Internal Medicine Sapporo Medical College
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Iimura Osamu
The 2nd Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Kobayashi Hiroaki
National Defense Medical College
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Takahashi Nobuki
Department Of Clinical Studies And Genetics Radiation Effects Research Foundation
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Kumagai Hiroo
Department Of Nephrology National Defense Medical College
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Ando Toshiaki
The Second Department of Internal Medicine, Sapporo Medical College
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Kobayashi Hiroaki
The 2nd Department of Internal Medicine, Sapporo Medical College, Sapporo
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Takigami Yoshiichi
The 2nd Department of Internal Medicine, Sapporo Medical College, Sapporo
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MIYAHARA MITSUO
The 2nd Department of Internal Medicine, Sapporo Medical College
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Ando Toshiaki
The Second Department Of Internal Medicine Sapporo Medical College
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Moriguchi Osami
The 2nd Department Of Internal Medicine Sapporo Medicine College
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Moriguchi Osami
Second Department Of Internal Medicine Sapporo Medical College
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Miyahara Mitsuo
The Second Department Of Internal Medicine Sapporo Medical College
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Iimura Osamu
The 2nd Department Of Internal Medicine Sapporo Medical College. Sapporo. Japan
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Iimura Osamu
The 2nd Dep.ofint. Med. Saporo Medical College
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Shimamoto Kazuaki
The 2nd Dept. Of Internal Med. Sapporo Medical Univ.
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Shimamoto Kazuaki
The 2nd Dep.ofint. Med. Saporo Medical College
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Komura Hiroaki
The 2nd Department Of Internal Medicine Sapporo Medical College
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Nakao Takashi
The 2nd Department of Internal Medicine, Sapporo Medical College
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TSUBOKURA TOSHIO
The 2nd Department of Internal Medicine, Sapporo Medical College
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ANDO TOSHIAKI
The 2nd Department of Internal Medicine, Sapporo Medical College
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Kobayashi Hiroaki
The 2nd Department Of Internal Medicine Sapporo Medical College
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Miyahara Mitsuo
The 2nd Department Of Internal Medicine Sapporo Medical College
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Tsubokura Toshio
The 2nd Department Of Internal Medicine Sapporo Medical College
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Mori Masaki
Division Of Gene Therapy Science Osaka University
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Takahashi Nobuyuki
Radiation Effects Research Foundation Hiroshima
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Ando Toshilaki
Second Department Of Internal Medicine Sapporo Medical College Sapporo
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Moriguchi Osami
Dept. Of Intern. Med. (section 2) Sapporo Med. Coll
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Kobayakawa Hiroshi
Second Department Of Internal Medicine Sapporo Medical College
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Kamihata Hiroshi
Department Of Pediatrics Osaka Medical College
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Kumagai Hiroo
Department Pediatrics Kobe University Graduate School Of Medicine
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Kikuchi Kenjiro
The 2nd Department Of Internal Medicine Sapporo Medical Colleg
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Iimura Osamu
The Secone Department Of Internal Medicine Sapporo Medical College
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Nakao Takashi
The 2nd Department Of Internal Medicine Sapporo Medical College
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Miyahara Mitsuo
Second Department Of Internal Medicine Sapporo Medical College
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Takigami Yoshiichi
The 2nd Department Of Internal Medicine Sapporo Medical College Sapporo
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