Repeated Sirolimus-Eluting Stent Implantation to Treat Sirolimus-Eluting Stent and Bare-Metal Stent Restenosis
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概要
- 論文の詳細を見る
Background: In-stent restenosis (ISR) remains a persistent, unresolved issue even in the era of percutaneous coronary intervention (PCI) using drug-eluting stents. The present study compares the clinical and angiographic outcomes of using sirolimus-eluting stents (SES) for re-intervention against ISR that was originally treated with sirolimus-eluting or bare-metal (BMS) stents. Methods and Results: This prospective single-center registry investigated 179 ISR lesions in 158 consecutive patients (53 lesions in 49, and 126 in 109 patients originally treated with SES and BMS, respectively), who had undergone re-intervention with SES. The patients were clinically and angiographically followed up at 8 months after re-PCI. The incidence of re-restenosis (29 vs 12%, P<0.01), ischemia-driven target lesion revascularization (TLR; 21 vs 8%, P<0.05) and major adverse cardiac events (MACE; 21 vs 9%, P<0.05) were significantly greater in ISR lesions originally treated with SES than in those originally treated with BMS at 8 months after re-PCI. Moreover, late luminal loss was significantly greater in the group with post-SES restenosis (P<0.05). Even after adjustment, post-SES restenosis was the only independent predictor of re-restenosis and MACE (P<0.05, each). Conclusions: Although the re-restenosis rate is acceptable, the incidence rates of late restenosis, ischemia-driven TLR and MACE are higher after repeated SES implantation to treat SES, than BMS restenosis. These results might affect the mid-term clinical outcomes of re-intervention with SES. (Circ J 2010; 74: 2329-2333)
- 2010-10-25
著者
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Kitamura K
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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Kikuchi Kenjiro
Second Department Of Internal Medicine Sapporo Medical College
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Shibata Yoshisato
Miyazaki Medical Association Hospital
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Nishihira Kensaku
Miyazaki Medical Association Hospital
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KITAMURA Kazuo
Division of Circulatory and Body Fluid Regulation, Faculty of Medicine, Department of Internal Medic
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Kamide Kei
国立循環器病センター 高血圧腎臓内科
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Kikuchi Kenjiro
The 2nd Department Of Internal Medicine Sapporo Medical College
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KIMURA Kenjiro
St. Marianna University School of Medicine
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Komamura Kazuo
Department Of Cardiovascular Dynamics Research Institute National Cardiovascular Center
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Kamide Kei
国立循環器病センター 予防検診部
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Kario Kazuomi
自治医科大学 地域医療学
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Asada Yujiro
Department of Pathology, Faculty of Medicine, University of Miyazaki
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Kitamura K
Division Of Circulatory And Body Fluid Regulation Faculty Of Medicine Department Of Internal Medicin
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Kitamura Kazuo
Division Of Cardiology Department Of Internal Medicine School Of Medicine Juntendo University
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Kitamura Kazuo
宮崎大学 医学部循環体液制御学
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Kurose K
Department Of Vascular Physiology Research Institute National Cardiovascular Center
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Kataoka Keiichiro
Kumamoto Ami Study Group
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Kawamura Keishiro
The Third Division Internal Medicine Osaka College
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Kohagura Kentaro
琉球大学医学部附属病院 血液浄化療法部
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Kayaba Kazunori
自治医科大学 地域医療学
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Kimura Kenjiro
東京大学 内科学
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IMAMURA Takuroh
Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki
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SHIBATA Yoshisato
Department of Cardiology, Miyazaki Medical Association Hospital
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Asada Y
Department Of Pathology Faculty Of Medicine University Of Miyazaki
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Kimura Kazuo
Division Of Cardiology Yokohama City University Medical Center
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Kitamura Kazuo
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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Kitamura K
Faculty Of Medicine Department Of Internal Medicine Division Of Circulatory And Body Fluid Regulatio
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Asada Yujiro
Department Of Pathology Faculty Of Medicine University Of Miyazaki
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Kuriyama Nehiro
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Nishihira Kensaku
Department of Cardiology, Miyazaki Medical Association Hospital
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Nakama Tatsuya
Department of Cardiology, Miyazaki Medical Association Hospital
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Mine Daigo
Department of Cardiology, Miyazaki Medical Association Hospital
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Nomura Katsumasa
Department of Cardiology, Miyazaki Medical Association Hospital
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Matsuyama Akihiko
Department of Cardiology, Miyazaki Medical Association Hospital
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Imamura Takuroh
Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medic
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Imamura Takuroh
Department Of Internal Medicine Circulatory And Body Fluid Regulation University Of Miyazaki
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Nishihira Kensaku
Departmennt Of Cardiology Miyazaki Medical Association Hospital
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Kinugawa Koh-ichiro
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Kohara Katsuhiko
Department Of Geriatric Medicine Ehime Unviersity School Of Medicine
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Kawamura Keishiro
Department Of Internal Medicine (iii) Osaka Medical College
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Asada Y
Department Of The First Pathology Miyazaki Medical College
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INOUE Yohei
Department of Scientific and Engineering Simulation, Graduate School of Engineering, Nagoya Institut
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Kikuchi Kan
Department Of Blood Purification Kidney Center Tokyo Women's Medical University
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木村 晃二
国立循環器病センター 心臓血管
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Shibata Yoshisato
Departmennt Of Cardiology Miyazaki Medical Association Hospital
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Kammatsuse Katsuo
Nihon University
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Ishikawa Tetsunori
Department Of Internal Medicine Miyazaki Social Insurance Hospital
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Kitamura Kazuo
Division Of Circulatory And Body Fluid Regulation Faculty Of Medicine Department Of Internal Medicin
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Imamura Takuroh
Division Of Circulatory And Body Fluid Regulation Department Of Internal Medicine Faculty Of Medicin
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Imamura Takuroh
Institute Of Angiocardiology And Cardiovascular Clinic Kyusyu University
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Shibata Yoshisato
Cardiovascular Division Miyazaki Shigun Ishikai Hospital
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Asada Yujiro
First Dep. Of Pathology Fac. Of Medicine Miyazaki Univ.
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Matsuyama Akihiko
Departmennt Of Cardiology Miyazaki Medical Association Hospital
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Mine Daigo
Departmennt Of Cardiology Miyazaki Medical Association Hospital
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Kato Ken
Division Of Gastrointestinal Oncology National Cancer Center Hospital
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Kubota Ken
Department Of Medicine Tokyo Metropolitan Komagome Hospital
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Kanatsu Kazuro
Department Of Internal Medicine Hyogo Hospital
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Nakama Tatsuya
Departmennt Of Cardiology Miyazaki Medical Association Hospital
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Kaziwara Ko
Department Of Cardiology Tenri Hospital
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Asada Yujiro
Department Of The First Pathology Miyazaki Medical College
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Inoue Yohei
Department Of Cardiology Miyazaki Medical Association Hospital
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Ashikaga Keiichi
Department Of Cardiology Miyazaki Medical Association Hospital
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ISHIKAWA Tetsunori
Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, University of Mi
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Kitamura Kouichi
Internal Medicine Nephrology And Hypertension St. Marianna University School Of Medicine
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Nishihira Kensaku
Department Of Cardiology Miyazaki Medical Association Hospital
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Kuriyama Nehiro
Department Of Cardiology Miyazaki Medical Association Hospital
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Kataoka Keiichiro
Department Of Physiological Chemistry And Metabolism Graduate School Of Medicine The University Of T
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Kitamura K
Department Of Medicine Tokyo Metropolitan Komagome Hospital
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Kadota K
Department Of Internal Medicine Hyogo Hospital
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Kanagawa Kenji
Research Institute National Cardiovascular Center
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Kudoh Kei
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Komamura Kazuo
Department Of Cardiovascular Medicine National Cardiovascular Center
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Kanatsu Kazuro
The 3rd Division Department Of International Medicine Faculty Of Medicine
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Asada Yujiro
Divisions Of Pathophysiology Department Of Pathology Faculty Of Medicine University Of Miyazaki
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Kitahara Koichi
Department Of Cardiology Sakakibara Heart Institute
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Ishikawa Tetsunori
Division Of Cardiology Miyakonojyo Regional Medical Center
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Nomura Katsumasa
Department Of Cardiology Miyazaki Medical Association Hospital
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Komamura Kazuo
National Cardiovascular Center Division Of Cardiovascular Medicine
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Kouno Kouichi
Department Of Medicine Division Of Hypertension And Cardiorenal Disease Dokkyo University School Of
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Kodama Kazuhisa
Cardiac Intensive Care Unit Of Osaka Police Hospital
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Kitamura Kazuo
Circulatory And Body Fluid Regulation Faculty Of Medicine University Of Miyazaki
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Sakamoto Yoshiko
Department Of Cardiovascular Medicine Saga University Faculty Of Medicine
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Kuwahara Koichiro
Department Of Medicine And Clinical Sciences Graduate School Of Medicine Kyoto University
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Matsuyama Akihiko
Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine
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Asaka Machiko
Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine
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Kitamura Kazuo
Division Of Cardiology Department Of Internal Medicine And Physiolocly Juntendo Univercity
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Kamide Kei
Division Of Cardiovascular Medicine Department Of Medicine School Of Medicine Jichi Medical Universi
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Kuwasako Kenji
Research Institute National Cardiovascular Center
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Imamura Takuroh
First Department Of Internal Medicine University Of Miyazaki
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Kitamuara Kazuo
First Department Of Internal Medicine University Of Miyazaki
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Kangawa Kenji
National Cerebral And Cardiovascular Center Research Institute
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Kimura Kenjiro
Department Of Cardiovascular Medicine Nephrology And Neurology Faculty Of Medicine University Of The
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Kangawa Kenji
Department Of Medicine And Geriatrics Osaka University Medical School:sakurabashi Watanabe Hospital
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Matsuyama Akihiko
Depart. Of Bioscience And Bioinformatics Kyushu Institute Of Technology
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Kikuchi Kenjiro
Department Of Cardiovascular Medicine Nephrology And Neurology Faculty Of Medicine University Of The
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Kitamura Kazuo
First Department Of Internal Medicine Miyazaki Medical College
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Kamide Kei
Cardiovascular Division Osaka Police Hospital
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Asada Yujiro
Department Of Pathology Faculty Of Medicine Miyazaki University
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