C-Reactive Protein Elevation and Rapid Angiographic Progression of Nonculprit Lesion in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
Background In non-ST-segment elevation acute coronary syndromes (NSTE-ACS), the relation of the level of high-sensitivity C-reactive protein (CRP) to the progression of atherosclerosis remains unclear. Methods and Results The study group comprised 153 patients with NSTE-ACS who underwent percutaneous coronary interventions (PCI) and follow-up (mean interval, 7 months) coronary angiography. Rapid progression was defined as ≥10% diameter reduction of a preexisting stenosis ≥50%, ≥30% diameter reduction of a stenosis <50%,development of a new stenosis ≥30% in a previously normal segment, or progression of any stenosis to total occlusion. Progressors had higher CRP levels on admission and at 48h after PCI, a higher level of low-density lipoprotein cholesterol at follow-up, a higher rate of multiple complex lesions, and a lower frequency of statin use at follow-up than nonprogressors. Multivariate analysis showed that admission CRP elevation (CRP level on admission ≥0.166mg/dl, median value; odds ratio (OR) 2.92, p=0.010), post-PCI CRP elevation (CRP level 48h after PCI ≥1.586mg/dl, median value; OR 2.67, p=0.022), and multiple complex lesions (OR 2.66, p=0.017) were independent predictors of rapid progression of nonculprit lesions. Conclusions Enhanced inflammatory response to PCI, as well as baseline inflammatory activity as reflected by CRP level, may be involved in the progression of atherosclerosis in NSTE-ACS.
- 社団法人日本循環器学会の論文
- 2008-11-20
著者
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Umemura Satoshi
Department of medical science and cardiorenal medcine, Yokohama City University Graduate School of M
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KOSUGE Masami
Division of Cardiology, Yokohama City University Medical Center
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KIMURA Kazuo
Division of Cardiology, Yokohama City University Medical Center
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UMEMURA Satoshi
Yokohama City University
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Kitamura K
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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HIBI Kiyoshi
Division of Cardiology, Yokohama City University Medical Center, Yokohama City University Graduate S
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MITSUHASHI Takayuki
Division of Cardiology, Yokohama City University Medical Center, Yokohama City University Graduate S
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ENDO Mitsuaki
Division of Cardiology, Yokohama City University Medical Center, Yokohama City University Graduate S
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EBINA Toshiaki
Division of Cardiology, Yokohama City University Medical Center, Yokohama City University Graduate S
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Nakachi Tatsuya
Division of Cardiology, Yokohama City University Medical Center
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Hashiba Katsutaka
Division of Cardiology, Yokohama City University Medical Center
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Nakati Tatsuya
Division Of Cardiology Yokohama City University Medical Center
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Ebina T
Division Of Cardiology Yokohama City University Medical Center
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Ebina Toshiaki
横浜市立大学附属市民総合医療センター 心臓血管センター
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Kosuge M
Division Of Cardiology Yokohama City University Medical Center
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Kosuge Masami
横浜市立大学附属市民総合医療センター 心臓血管センター
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Kosuge Masami
Division Of Cardiology Yokohama City University Medical Center
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Kosuge Masami
Yokohama City University School Of Medicine Cardiovascular Center
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Hibi Kiyoshi
Division Of Cardiology Yokohama City University Medical Center
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Endoh Mitsuaki
Division Of Cardiology Yokohama City University Medical Center Yokohama City University Graduate Sch
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Mituhashi Takayuki
Division Of Cardiology Yokohama City University Medical Center Yokohama City University Graduate Sch
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Matsumoto Katsumi
横浜市立大学 第二内科学教室
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Matsushita Kohei
横浜市立大学医学部附属病院 循環器内科
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Kiyokuni Masayoshi
横浜市立大学附属市民総合医療センター 心臓血管センター
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Minami Kazutoshi
横浜市立大学附属市民総合医療センター
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Hashiba Katsutaka
The Division Of Cardiology Yokohama City University Medical Center
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Kihara Minoru
横浜市立大学 医学部循環器内科
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Minami Kazutoshi
Yokohama City University Medical Center
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Matsushita Kohei
Second Department Of Internal Medicine Urafune Hospital Of Yokohama City University
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Matsumoto Katsumi
Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine
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Kohagura Kentaro
琉球大学 第三内科
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Kosuge Masami
横浜市立大学 心臓血管セ
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Ebina Toshiaki
Division Of Cardiology Yokohama City University Medical Center
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Hashiba Katsutaka
Division Of Cardiology Yokohama City University Medical Center
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Matsumoto K
Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine
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Kimura Kazuo
Division Of Cardiology Yokohama City University Medical Center
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Kammatsuse Katsuo
Nihon University
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Minami Kazutoshi
Department Of Cardiology Yokohama City University Medical Center
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Kikuchi Miyako
Yokohama City University School Of Medicine Cardiovascular Center
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Umemura S
Department Of Second Internal Medicine Yokohama City University School Of Medicine
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Minamizawa Kousuke
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Minamisawa Kohsuke
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Umemura Satoshi
Department Of Internal Medicine Ii Yokohama City University School Of Medicine
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Kuwahara Koichiro
Department Of Medicine And Clinical Sciences Graduate School Of Medicine Kyoto University
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Uemura Shiro
1st Dept. Of Int. Med. Nara Medical University
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Endo Mitsuaki
Division of Cardiology, Yokohama City University Medical Center
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- OE-254 Overexpression of ATRAP(AT1 receptor-assosiated protein) in cardiomyocytes completely inhibits cardiac hypertrophy induced by Angiotensin(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of th