Elevated Plasma Osteopontin Levels Were Associated With Osteopontin Expression of CD4^+ T Cells in Patients With Unstable Angina

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Background Plaque instability in patients with unstable angina (UA) is associated with stimulated CD4^+ T cells, so the present study investigated whether there is a relationship among plaque instability, osteopontin and CD4^+ T cells. Methods and Results Peripheral blood mononuclear cells were collected from 51 consecutive patients with UA, 60 patients with stable angina (SA), and 39 patients with chest pain syndrome (CPS). Osteopontin-producing CD4^+ T cells were quantified by flow cytometry. Plasma osteopontin levels (ng/ml) were measured by ELISA and were higher in patients with UA (792.0±316.7) than in those with SA (626.0±195.0, p<0.005) or CPS (594.7±239.4, p<0.005). The frequency (%) of osteopontin-producing CD4^+ T cells was higher in patients with UA (26.7±13.3) than in those with SA (19.5±11.1, p<0.05) or CPS (16.6±9.0, p<0.005). Furthermore, the plasma osteopontin level correlated with the frequency of osteopontin-producing CD4^+ T cells (r=0.327, p=0.0004), as did the high-sensitivity C-reactive protein level (r=0.360, p=0.0002). Conclusions The plasma osteopontin levels are elevated in patients with UA, accompanied by an increase in the number of osteopontin-production of circulating CD4^+ T cells. Circulating CD4^+ T cells may play a role through osteopontin in the pathophysiology of UA.
社団法人日本循環器学会の論文
2006-06-20