THE EFFECT OF INOTROPIC DOSE OF DOBUTAMINE DURING REPERFUSION ON MYOCARDIAL INFARCT SIZE
スポンサーリンク
概要
- 論文の詳細を見る
We examined whether dobutamine infusion during reperfusion modifies myocardial infarct size in a rabbit ischemia-reperfusion model. Prior to the infarct size study, the hemodynamic response to dobutamine.5, 10, and 15μg/kg/min i.v. was evaluated in the rabbit model. Ten μg/kg/min of dobutamine increased the left ventricular dp/dt max by 34.0±4.9% (n=7) and the myocardial blood flow from 0.86±0.16 to 2.19±0.57 ml/min/g without change in the collateral blood flow (n=4). The heart rate, systolic and diastolic blood pressures were elevated by only 4.7±1.0%, 9,4±3.0%, and 8.0±3.7%, respectively (n=7). In the infarct size study, a coronary branch was occluded for 30 min and then reperfused. Seventy-two hours after reperfusion, the myocardium supplied by the occluded artery (area at risk, AAR) and the infarcted area were determined by fluorescent particles and histology (hemotoxylin-eosin and modified Mallory's staining), respectively. In the dobutamine treated group (DB group), 10μg/kg/min of dobutamine were infused for 30 min starting immediately after reperfusion, and a comparable volume of saline was infused in the control group. Hemodynamic parameters and the size of AAR were comparable in the control and DB groups. Myocardial infarct size, expressed as the percentage of AAR, was 45.1±3.9% in the control (n=11) and 40.2±2.4% in the DB group (n=10), which was not significantly different. These findings indicated that the isotropic dose of dobutamine administered during reperfusion did not cause myocardial necrosis by disturbing the recovery process of the myocardium from ischemic injury.
- 社団法人日本循環器学会の論文
- 1989-12-20
著者
-
Iimura Osamu
The Second Department Of Internal Medicine Sapporo Medical College
-
Miura Tetsuji
The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
-
Tsuchida Akihito
The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
-
OGAWA TAKASHI
The Second Department of Internal Medicine, Sapporo Medical College
-
IWAMOTO TOSHIHIRO
The Second Department of Internal Medicine, Sapporo Medical College
-
Matsuki Takayuki
Department of Cardiology, Shin-Nittetsu Muroran General Hospital
-
Iwamoto Toshihiro
The Second Department Of Internal Medicine Sapporo Medical College
-
Miura Tetsuji
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
-
Miura Tetsuji
The Second Department Of Internal Medicine Sapporo Medical College
-
Matsuki Takayuki
Department Of Cardiology Shin-nittetsu Muroran General Hospital
-
OOIWA HITOSHI
The Second Department of Internal Medicine, Sapporo Medical College
-
DOWNEY JAMES
Department of Physiology, College of Medicine, University of South Alabama
-
SHIZUKUDA YUKITAKA
The Second Department of Internal Medicine, Sapporo Medical College
-
ADACHI TAKEO
The Second Department of Internal Medicine, Sapporo Medical College
-
Iimura Osamu
The Second Department Of Internal Medicine Sappolo Medical College
-
Tsuchida Akihito
The Second Department Of Internal Medicine Sapporo Medical College
-
Downey James
Department Of Physiology College Of Medicine University Of South Alabama
-
Downey James
Department Of Medical Physiology University Of South Alabama
-
Adachi Takeo
The Second Department Of Internal Medicine Sapporo Medical College
-
Ooiwa Hitoshi
The Second Department Of Internal Medicine Sapporo Medical College
-
Matsuki Takayuki
Department Of Physiology College Of Medicine University Of South Alabama
-
Shizukuda Yukitaka
The Second Department Of Internal Medicine Sapporo Medical College
-
Ogawa Takashi
The Second Department Of Internal Medicine Sapporo Medical College
-
IIMURA OSAMU
The Second Department of Internal Mdicine, Sapporo Medical College
関連論文
- Quadricuspid aortic valve associated with aortic stenosis and regurgitation : report of a case and a review of the literature
- Visceral Obesity in Japanese Patients with Metabolic Syndrome : Reappraisal of Diagnostic Criteria by CT Scan
- Noninvasive Assessment of Left Atrial Function by Strain Rate Imaging in Patients with Hypertension : A Possible Beneficial Effect of Renin-Angiotensin System Inhibition on Left Atrial Function
- Persistent Insulin-Sensitizing Effects of Sarpogrelate Hydrochloride, a Serotonin 2A Receptor Antagonist, in Patients With Peripheral Arterial Disease
- Long-Term Outcome of Implanted Cardioverter Defibrillators in Survivors of Out-of-Hospital Cardiac Arrest of Cardiac Origin
- FRAGMENTATION HEMOLYSIS IN A PATIENT WITH HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY AND MITRAL VALVE PROLAPSE
- THE INHIBITORY EFFECT OF NIFEDIPINE ON CARDIAC FUNCTION AND NORADRENALINE RELEASE DURING CARDIAC SYMPATHETIC NERVE STIMULATION : Cardiovascular Drugs (II) : V : 48 Annual Scientific Meeting, Japanese Circulation Society
- Plasma Noradrenaline Concentration and Pressor Response to Infused Noradrenaline in Patients with Borderline Hypertension, and Mild or Moderate Essential Hypertension : SYMPOSIUM ON BLOOD PRESSURE AND VASOACTIVE SUBSTANCES
- THE ROLE OF L-CARNITINE IN THE PATHOGENESIS OF CARDIOMEGALY IN PATIENTS WITH CHRONIC HEMODIALYSIS
- PLASMA ANGIOTENSIN II LEVELS IN ESSENTIAL AND SECONDARY HYPERTENSIVES : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
- Role of Adiponectin in Insulin-Resistant Hypertension and Atherosclerosis
- Chinese Medicine, Jiang-Tang-Ke-Li, Improves Insulin Resistance by Modulating Muscle Fiber Composition and Muscle Tumor Necrosis Factor-α in Fructose-Fed Rate
- IS073 Infarct Size-limiting Effect of Ischemic Preconditioning is Disturbed by Post-infarct Ventricular Remodeling via Angiotensin II Type 1 Receptor Activation
- IS071 Infarct Size Limitation by Sodium-hydrogen Exhange Inhibition Requires Activation of Mitochondrial ATP-senstive K Channeles
- IS065 ATP-sensitive potassium channels may play a permissive role in cardioprotection by the Na^+-H^+ exchange inhibitor HOE642 against ischemia/reperfusion injury
- INHIBITION OF THROMBOXANE A2 SYNTHETASE FAILED TO LIMIT MYOCARDIAL INFARCT SIZE IN A RABBIT ISCHEMIA-REPERFUSION MODEL
- Clinical Pathology and Treatment of Renin-Angiotensin System 4. Renin-Angiotensin System and Insulin Resistance
- Endothelium-dependent Coronary Response is Impaired in the Myocardium at an Early Phase of Post-infarct Remodeling
- 3 Diagnosis Procedure Combination in Private Hospitals(DPC and Clinical Practice of Cardiovascular Medicine, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Development and Progression of Atherosclerotic Disease in Relation to Insulin Resistance and Hyperinsulinemia
- PE-247 Detection of Ischemia in Patients with Acute Chest Pain by using Resting and Subsequent ATP Stress 99mTc-Tetrofosmin Myocardial SPECT(Nuclear Cardiology 9 (I) : PE42)(Poster Session (English))
- Hepatocyte Growth Factor and 24-Hour Ambulatory Blood Pressure Monitoring
- OJ-104 Connexin-43 Contributes to Pro-survival Akt/GSK-3β signaling And Cardimyocyte Protection in a Receptor-specifit Manner(Cell death, apoptosis/necrosis(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- OJ-103 Role of Intra-mitochondrial GSK-3β in Bax Regulation And Antiapoptotic Resistance of Cardiomyocytes(Cell death, apoptosis/necrosis(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-268 Ischemic Preconditioning Modifies Interactions between Connexin43 and Protein Kinases during Myocardial Ischemia(Myocardial ischemia-reperfusion, basic/clinical-4 (IHD) PE45,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of
- OE-080 Role of GSK-3 β as a Crucial Determinant of Anti-infarct Tolerance of the Myocardium(Acute myocardial infarction, basic-1 (IHD) OE14,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-026 Activation of ERK and Suppression of Calcineurin are Interacting Mechanisms of Cardioprotection Afforded by δ-opioid Receptor Activation(Myocardial ischemia-reperfusion, basic/clinical-1 (IHD) OE5,Oral Presentation (English),The 70th Anniversary An
- Activation of δ-Opioid Receptor Suppresses Myocardial Ischemic Injury by ERK Activation during the Early Phase of Ischemia(Acute Myocardial Infarction, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Activation of the δ-opioid Receptor Induces Phosphorylation of Connexin43 at Ser368 by PKC-ε and Reduces Myocardial Infarct Size(Myocardial Ischemia-reperfusion, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Erythropoietin Reduces Myocardial Ischemic Injury, but not Reperfusion Injury, Through Activation of the Pl3k/Akt Pathway(Myocardial Ischemia-reperfusion, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-069 Suppression of Border Zone Remodeling by G-CSF/M-CSF Treatment Improves Ventricular Function after Infarction(Acute Myocardial Infarction, Basic 3 (IHD) : PE12)(Poster Session (English))
- OE-080 Shedding of TNF-a by Activation of ADAM17 Contributes to Activation of Tyrosine Kinase-Mediated Pathway in Ischemic Preconditioning(Myocardial Ischemia-Reperfusion, Basic and Clinical 1 (IHD) : OE10)(Oral Presentation (English))
- OE-079 Suppression of Gap Junction Permeability Is a Mechanism of Cardioprotection Afforded by Activation of the Mitochondrial KATP Channel(Myocardial Ischemia-Reperfusion, Basic and Clinical 1 (IHD) : OE10)(Oral Presentation (English))
- OE-003 Mechanisms of Improvement in Post-infarct Ventricular Function by M-CSF in the rat : Increased Myocyte Regeneration vs. Modulation of Infarct Repair(Acute Myocardial Infarction, Basic 1 (IHD) : OE1)(Oral Presentation (English))
- FRS-084 Ischemia/Reperfusion Up-regulates Egr-1 Expression by an NO and ERK-mediated Mechanism in the Heart.(NO and Cardiovascular System (H) : FRS10)(Featured Research Session (English))
- Microtubules Play a Major Role in Signal Transduction in the Mechanism of Cardioprotection Afforded by Ischemic Preconditioning
- Metaloprotease-Disintegrin Is Involved in Tyrosine Kinase-Mediated Signaling in Ischemic Preconditioning
- EFFECTS OF INDOMETHACIN ON BLOOD PRESSURE AND RENAL SODIUM METABOLISM IN ESSENTIAL HYPERTENSION : WITH SPECIAL REFERENCE TO PLASMA RENIN ACTIVITY : Hypertension(I) : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- PE-545 Distinct Roles of FOXO Subtypes in SIRT1-mediated Mn-SOD Up-regulation under Oxidative Stress(PE091,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- DPE-012 Activation of SIRT1, a Histone/Protein Deacetylase, by Resveratrol Up-regulates MnSOD and Suppresses the Progression of Heart Failure(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanes
- Gap Junction Is an End-Effector of Cardioprotection in Ischemic Preconditioning
- Contribution of gap junction communication to myocardial necrosis during ischemia/reperfusion
- THE ROLE OF Na^+-k^+ ATPase INHIBITOR IN PRESSOR RESPONSE TO INFUSED NORADRENALINE IN NORMOTENSIVE SUBJECTS : Sympathetic Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Early Defibrillation and Circulatory Support Can Provide Better Long-Term Outcomes Through Favorable Neurological Recovery in Patients With Out-of-Hospital Cardiac Arrest of Cardiac Origin
- OE-036 Roles of GSK-3 β in Myocardial Protection Afforded by Activation of the Mitochondrial K_ Channel(OE06,Myocardial Ischemia-reperfusion (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
- OE-010 Distinct Roles of PKC ε and p38MAPK in Preconditioning-induced Modulation of Gap Junction Permeability during Ischemia(OE02,ACS/AMI (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-008 Homodimeric Erythropoietin (EPO) Receptor Provokes More Potent and Distinct Cytoprotective Signaling Compared with Heterodimeric EPO-common-β Subunit Receptor in the Heart(OE02,ACS/AMI (Basic) (IHD),Oral Presentation (English),The 73rd Annual Scien
- FRS-044 ROS-mediated Enhancement of ANT-cyclophilin-D Interaction Underlies Reduced Anti-infarct Tolerance and Lost Response of Cardiomyocytes to Pro-survival Signaling in Hypertrophied Hearts(FRS9,Novel Mechanisms of Myocardial Ischemia (IHD),Featured Re
- PJ-005 Impairment of Myocardial Response to Erythropoietin-Induced Protection in Hypertensive Hypertrophied Hearts(Acute myocardial infarction, basic(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-333 Resveratrol, An Activator of Longevity Protein SIRT1, Suppresses Progression of Heart Failure Through SIRT1-mediated Cardiomyocyte Protection Against Oxidant Stress(Heart failure, basic(03)(M),Poster Session(English),The 72nd Annual Scientific Meet
- PE-222 Alteration of Akt-GSK-3β Signaling by ER Stress Underlies Failure of Erythropoietin to Protect Diabetic Hearts(Myocardial ischemia/reperfusion, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circu
- OE-309 Relationship of the Mitochondrial K_ Channel and GSK-3β in Enhancement of Myocardial Tolerance against Infarction(Myocardial ischemia/reperfusion, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Jap
- PE-443 Role of Glycogen Synthase Kinase-3 β in Cardiomyocyte Protection by Erythropoietin(Heart failure, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-072 Ischemic Preconditioning Prevents Ischemia/reperfusion-Induced Dephosphorylation of Mitochondrial Connexin-43 in a Protein Complex with Adenine Nucleotide Translocator(Myocardial ischemia/reperfusion, basic/clinical-2, The 71st Annual Scientific Me
- PE-067 Relationships between p38MAPK and PKC in Connexin43-mediated Gap Junction Modulation by Ischemic Preconditioning(Myocardial ischemia/reperfusion, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-312 Nuclear Localization of SIRT1, a Novel Mechanism of Cardiomyocyte Protection in Failing Hearts, is Achieved by PI3K/Akt Signaling(Heart failure, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-126 Modulation of Mitochondrial Permeability Transition Pore Complex in GSK-3β-mediated Cardiomyocyte Protection(Myocardial ischemia/reperfusion, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-053 Cardioprotective Signaling Provoked by Erythropoietin is Impaired in Diabetic Myocardium(Acute myocardial infarction, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-046 Predictors of Improvement of Exercise Capacity by Nitrates in Experimental Heart Failure(Heart failure, basic-7 (M) PJ8,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-601 Molecular Mechanisms of Nucleo-cytoplasmic Shuttling of SIRT1, a Histone Deacetylase, and Its Pathopysicological Roles in Cardiomyocytes(Molecular biology, myocardium-2 (M) PE106,Poster Session (English),The 70th Anniversary Annual Scientific Meeti
- Impact of Abnormal Glucose Tolerance, Hypertension and Other Risk Factors on Coronary Artery Disease
- Pulse Pressure Correlates to Plasma BNP Level in Essential Hypertension Patients
- The significance of the ability of cGMP production induced by exogenous ANP infusion in chronic heart failure
- Intracranial Pheochromocytoma : A Case of Noradrenaline-Secreting Glomus Jugulare Tumor
- Natriuretic Peptide Receptor Function and Prognosis in Heart Failure Patients
- -25- EFFECT OF CORONARY COLLATERAL FLOW ON THE OCCURRENCE OF SERIOUS VENTRICULAR ARRHYTHMIAS DURING EARLY PHASE OF ACUTE MYOCARDIAL ISCHEMIA : CORRELATION WITH CARDIAC METABOLISM AND HEMODYNAMICS : Coronary Circulation : FREE COMMUNICATIONS(I) : PROCEEDIN
- Normal BMIPP imaging is an excellent prognostic sign in patients with angina pectoris : Comparison with stress myocardial perfusion imaging
- THE EFFECT OF INOTROPIC DOSE OF DOBUTAMINE DURING REPERFUSION ON MYOCARDIAL INFARCT SIZE
- HUMAN SUPEROXIDE DISMUTASE FAILED TO LIMIT THE SIZE OF MYOCARDIAL INFARCT AFTER 20-, 30-, OR 60-MINUTE ISCHEMIA AND 72-HOUR REPERFUSION IN THE RABBIT
- MORPHOLOGICAL ASSESSMENT OF LEFT VENTRICULAR WALL AND VENTRICULAR ANEURYSM BY THALLIUM-201 MYOCARDIAL EMISSION COMPUTED TOMOGRAPHY
- THE ROLE OF THE RENAL KALLIKREIN-KININ-KININASE SYSTEM IN ESSENTIAL HYPERTENSION AND PRIMARY ALDOSTERONISM : Hypertension (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- MASSIVE MYOCARDIAL CALCIFICATION OF RIGHT AND LEFT VENTRICLES FOLLOWING ACUTE MYOCARDITIS COMPLICATED WITH RHABDOMYOLYSIS-INDUCED ACUTE RENAL FAILURE
- The Role of the Renal Kallikrein-kinin System in Sodium Metabolism in Normal and Low Renin Essential Hypertension : The 12th Conference on the Pathogenesis of Hypertension
- Association of Insulin Resistance and Hyperinsulinemia with Disturbed Lipid Metabolism in Patients with Essential Hypertension
- A Very Sensitive Direct Radioimmunoassay System for Plasma Angiotensin II and its Clinical Application in Various Hypertensive Diseases : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- The Pathophysiological Role of Renal Dopaminergic Activity in Patients with Essential Hypertension
- The Pathophysiological Role of Blood Ionized Calcium in Essential Hypertension
- Sympathetic Nerve Activity, Plasma Renin Activity and Water-Sodium Balance in Obese Patients with Essential Hypertension : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- PE-115 Activation of ERK Compensates Disrupted PI3K-Akt Signaling in EPO-induced Cardioprotection of Post-infarct Remodeled Hearts(Acute myocardial infarction, basic-3 (IHD) PE20,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of t
- Effects of Hyperinsulinemia under the Euglycemic Condition on Calcium and Phosphate Metabolism in Non-Obese Normotensive Subjects
- THE DUAL EFFECTS OF HEMODIALYSIS ON CARDIAC FUNCTION ASSESSED BY PULSED DOPPLER ECHOCARDIOGRAPHY
- Insulin Resistance and Hypertension in Japanese
- STUDY ON THE ATHEROSCLEROSIS MECHANISM IN CHRONIC HEMODIALYSIS
- -228-STUDIES ON SEASONAL CHANGES OF BLOOD PRESSURE IN THE COLD CIRCUMSTANCES
- BENIGN VENTRICULAR TACHYCARDIA IN SYSTEMIC SARCOIDOSIS : A Case of False Tendon
- -537- IS ATHEROSCLEROSIS ACCELERATED BY CHRONIC HEMODIALYSIS?
- SLOW CONTINUOUS HEMODIALYSIS : New Therapy for Acute Renal Failure in Critically III Patients : Part 1. Theoretical Consideration and New Technique
- TUBERCULOSIS ON REGULAR HEMODIALYSIS : A Case of Pericardial Tamponade
- Serial Alterations and Prognostic Implications of Myocardial Perfusion and Fatty Acid Metabolism in Patients With Acute Myocardial Infarction
- Perfusion-BMIPP Mismatched Area Is Related to Future Cardiac Events in Patients Survived Following Acute Myocardial Infarction
- Excretion of Human Urinary Kallikrein Quantity Measured by a Direct Radioimmunoassay of Human Urinary Kallikrein in Patients with Essential Hypertension and Secondary Hypertensive Diseases : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- EFFECT OF SALINE INFUSION ON THE RENAL KALLIKREIN-KININ SYSTEM, PROSTAGLANDINS AND SODIUM METABOLISM IN ESSENTIAL HYPERTENSION : Hypertension (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- EFFECT OF DOPAMINE INFUSION ON THE RENAL KALLIKREIN-KININ SYSTEM AND RENAL SODIUM METABOLISM IN ESSENTIAL HYPERTENSION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
- SLOW CONTINUOUS HEMODIALYSIS : New Therapy For Acute Renal Failure in Critically III Patients : Part 2. Animal Experiments and Clinical Implication
- THE PATHOPHYSIOLOGICAL ROLE AND DYNAMICS OF RENAL DOPAMINE, KALLIKREINKININ AND PROSTAGLANDIN SYSTEMS IN ESSENTIAL HYPERTENSION : Hypertension (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SO
- Prognostic Value of Myocardial Fatty Acid Imaging in Patients with Coronary Heart Disease
- URINARY EXCRETIONS OF PREKALLIKREIN IN VARIOUS HYPERTENSIVE DISEASES : Hypertension(I) : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- Plasma Antidiuretic Hormone Levles in Patients with Normal and Low Renin Essential Hypertension, and Secondary Hypertension
- Validation of Automated Quantitation of Myocardial Perfusion and Fatty Acid Metabolism Abnormalities on SPECT Images
- Bartter's Syndrome with Gouty Arthritis.