COMPARISON OF THE EFFECTS OF DOBUTAMINE AND ISOPROTERENOL IN ISCHEMIC HEARTS BY PHOSPHORUS-31 NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
スポンサーリンク
概要
- 論文の詳細を見る
We compared the effects of 2 inotropic agents, dobutamine and isoproterenol, on regional coronary blood flow, contractile function, hemodynamics and levels of phosphate compounds in the acutely ischemic canine heart. Dogs were instrumented to determine regional coronary blood flow (non-radioactive microsphere method), contractile function (sonomicrometry), and hemodynamics. Myocardial phosphate compounds were measured simultaneously by the phosphate-31 (^<31>P) magnetic resonance spectroscopic technique. Both drugs augmented the global performance of the heart, but produced no significant improvement in regional contractile function in the ischemic region. Isoproterenol significantly increased the ratio of inorganic phosphate to phosphocreatine in the ischemic region, as compared to dobutamine. However, no significant differences were seen in myocardial lactate consumption with inotropic stimulation between the 2 groups. ^<31>P magnetic resonance spectroscopy could be used to differentiate between the effects of dobutamine and isoproterenol on energy metabolism in ischemic myocardium despite the lack of significant differences in regional function and myocardial lactate consumption. The significant tachycardia without an augmentation of systemic blood pressure induced by isoproterenol may account for this unfavorable effect on myocardial energy metabolism.
- 社団法人日本循環器学会の論文
- 1994-04-20
著者
-
Yanagi Shiro
Division Of Cardiology Fuchu Hospital
-
Takeuchi Kazuhide
First Department of Internal Medicine Osaka City University Medical School
-
Takeuchi Kazuhide
大阪市立大学 医学研究科循環器病態内科学
-
Takeuchi Kazuhide
The First Department Of Internal Medicine Osaka City University Medical School
-
Takeda Tadanao
First Department of Internal Medicine, Osaka City University Medical School
-
ISHIKAWA Makoto
Bioenergetics Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
-
Takeda Tadanao
First Department Of Internal Medicine Osaka City University Medical School
-
Takeda Tadanao
The First Department Of Internal Medicine Osaka City University Medical School
-
Miura Iwao
Bioenergetics Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
-
YANAGI SHIRO
The First Department of Internal Medicine, Osaka City University Medical School
-
Ishikawa Makoto
Bioenergetics Research Center Tokusima Research Institute Otsuka Pharmaceutical Company Ltd.
-
Takeda Tadanao
1st Department Of Internal Medicine Osaka City University Medical School
-
Miura Iwao
Bioenergetics Research Center Tokusima Research Institute Otsuka Pharmaceutical Company Ltd.
-
Miura Iwao
Bioenergetic Research Center Tokushima Research Institute Otuka Pharmaceutical Co. Ltd.
関連論文
- Method Analysis for Optimal Continuous Imaging Using Intravascular Optical Coherence Tomography(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 10 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-067 Relationship Between Patterns of Calcification and Arterial Remodeling of Culprit Lesions, Comparing Acute Coronary Syndromes with Stable Angina(Acute Coronary Syndrome, Basic/Clinical 3 (IHD) : OE9)(Oral Presentation (English))
- Slow-Flow Phenomenon during Percutaneous Coronary Intervention in Acute Myocardial Infarction : An Intravascular Ultrasound Study
- The Influences of Hemodialysis and AV-Shunt on Bilateral Internal Thoracic Artery Flows : An Ultrasound Study
- OJ-003 Prevention of In-stent Neointimal Proliferation by Pioglitazone Study(POPPS)(Coronary revascularization, PCI(05)(IHD),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-201 Acute Hemodynamic Benefits of Biatrial Atrioventricular Sequential Pacing with the Optimal Atrioventricular Delay. : Comparison with Single Atrial Atrioventricular Sequential Pacing.(Arrhythmia, Non-Pharmacological Therapy 7 (A) : PJ34)(Poster Sess
- Acute Hemodynamic Benefits of Biatrial Atrioventricular Sequential Pacing : Comparison with Single Atrial Atrioventricular Sequential Pacing
- A Reverse Flow-Metabolism Mismatch Pattern : A New Marker of Viable Myocardium With Greater Contractility During Dobutamine Stress Than Myocardium With a Flow-Metabolism Mismatch Pattern
- Effects of Metabolically Ischemic, But Viable, Myocardium on QT Dispersion in Patients With Acute Myocardial Infarction : A Study With Resting I-123-BMIPP/Thallium-201 Myocardial Single-Photon Emission Computer Tomography
- Transient myocardial perfusion abnormality and prolonged impairment of sympathetic nervous system in patients with Ampulla cardiomyopathy "Takotubo Cardiomyopathy"
- Novel Method for Assessing Myocardial Perfusion : Visualization and Measurement of Intramyocardial Coronary Blood Flow in the Entire Left Ventricular Wall Using Contrast Enhanced, High Frequency Doppler Echocardiography
- Angiotensin II Type 1-Receptor Antagonist Candesartan Cilexitil Prevents Left Ventricular Dysfunction in Myocardial Infarcted Rats
- Doppler Echocardiographic Assessment and Cardiac Gene Expression Analysis of the Left Ventricle in Myocardial Infarcted Rats
- Effect of Manidipine Hydrochloride, a Calcium Antagonist, on Isoproterenol-Induced Left Ventricular Hypertrophy
- -P613- Calcium channel antagonist prevents cardiac hypertrophy induced by isoproterenol(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0907- The effect of TCV-116, angiotensin II type I receotor antagonist, ont the cardiac phenotype and extracelullar matrix in left ventricular remodeling after myocardial infarction.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCU
- -0669- Isosorbide Dinitrate Suppresses Protooncogene Expression on Ischemia-Reperfusion Injury(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- The role of angiotensin II type l receptor to the left ventricular remodeling after myocardial infarction
- Protooncogene expression on ischemia-reperfusion injury
- Progression of Post-Arteritis Lesions into Atherosclerotic Plaques in Kawasaki Disease(Congenital Heart Disease/Kawasaki's Disease 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-136 Assessment of Myocardial Ischemia Using New Three-Dimensional Dobutamine Stress Echocardiography(Echo/Doppler 6 (I) : PJ23)(Poster Session (Japanese))
- PJ-022 Feasible and Accurate Measurement of Left Ventricular Volume and Ejection Fraction by New Real-Time Three-Dimensional Echocardiography(Echo/Doppler 2 (I) : PJ4)(Poster Session (Japanese))
- OJ-085 Simplified Three-dimensional Measurement of Left Ventricular Volume and Ejection Fraction Using Automated Contour Tracking Method(Echo/Doppler 1 (I) : OJ11)(Oral Presentation (Japanese))
- FRS-007 Value of Coronary Flow Reserve Measurement in Three Major Coronary Arteries as a Screening Tool for Detecting Myocardial Ischemia(Ultrasound Medicine in Cardiology (I) : FRS1)(Featured Research Session (English))
- Coronary Flow Reserve Measurement Still Remains Useful in Diagnosing Coronary Stenosis Even in Patients with Coronary Risk Factors
- The Effect of Oral Glucose Loading on the Coronary Circulation in Healthy Young Adults : Analysis by Transthoracic Doppler Echocardiography
- Automated Quantification of Left Ventricular Function in Patients with Ischemic Heart Disease by Using Biplane Advanced Automated Contour Tracking Method
- -1236-CIRCULATING IMMMUNOREACTIVE ENDOTHELIN IN ISCHEMIC HEART DISEASE : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PJ-394 Beneficial Effects of Erythropoietin on Cardiac Remodeling after Myocardial Infarction(Growth factor/Cytokine-3 (H) PJ67,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- ROLE OF NITRIC OXIDE IN THE VASODILATORY RESPONSES TO ACETYLCHOLINE AND BRADYKININ IN PERFUSED HEARTS
- ASSESSMENT OF SUPERIOR VENA CAVAL BLOOD FLOW VELOCITY IN ISCHEMIC HEART DISEASE
- CARDIAC FUNCTION OF PATIENTS WITH ESSENTIAL HYPERTENSION DURING EXERCISE AND ISOPROTERENOL INFUSION
- FACTOR ANALYSIS FOR EVALUATING ASYNERGY OF MYOCARDIAL INFARCTION : Nuclear Cardiology (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Novel Method for Myocardial Contrast Echocardiography Using LevovistTM : Usefulness of Myocardial Blood Volume Map For Diagnosing Ischemic Heart Disease(Echo/Doppler 13 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Coronary Flow Pattern Using Transthoracic Doppler Echocardiography in Emergency Room Noninvasively Predicts TIMI Grade in Patients With Acute Coronary Syndrome(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 4 (IHD), The 69th Annual Scientific
- Predictive Value of Sympathetic Myocardail Denervation for Abnormal Coronary Flow Reserve in Patients with Non-Ischemic Dilated Cardiomyopathy
- Influences of Sublingual Nitroglycerin on Coronary Flow Velocity as Detected by Transthoracic Color Doppler Echocardiography
- Detection of Restenosis after Primary Coronary Intervention with Coronary Flow Reserve Using Transthoracic Color Doppler Echocardiography
- Noninvasive Detection of Coronary Artery Using Transthoracic Doppler Echocardiography in Patients with Suspected Acute Myocardial Infarction in Emergency Room
- Quantitative Assessment of Myocardial Perfusion by Intravenous Myocardial Contrast Echocardiography With Dobutamine Stress for Detection of Coronary Stenosis in Humans
- Reverse Redistribution of Thallium-201 Myocardial Single Photon Emission Tomography and Contractile Reserve
- EXTENSIVE SPECIFICALLY LOCALIZED MYOCARDIAL CALCIUM DEPOSITION IN A HEMODIALYSIS PATIENT
- TWO-DIMENSIONAL AND DOPPLER ECHOCARDIOGRAPHIC FINDINGS IN A CASE OF SUBAORTIC "FIBROUS SAC"
- SIGNIFICANCE OF Q WAVE DISAPPEARANCE IN THE CHRONIC PHASE FOLLOWING TRANSMURAL ACUTE MYOCARDIAL INFARCTION
- -0847-CLINICAL SINGNIFICANCE OF PLATELET-DERIVED GROWTH FACTOR (PDGF) IN THE RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY (PTCA) : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE COMPLEMENT SYSTEM IN THE ACUTE PHASE OF MYOCARDIAL INFARCTION
- ASSESSMENT OF MECHANISMS OF CALCIUM PARADOX USING 31P-MRS : Pathophysiology : 53 Annual Scientific Meeting, Japanese Circulation Society
- -140-THE ENDOMYOCARDIAL BIOPSY FINDINGS AND CLINICAL FEATURES OF HEAVY DRINKERS WITH HEART FAILURE IN COMPARISON WITH THOSE OF PATIENTS OF DILATED CARDIOMYOPATHY : Cardiomyopathy : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING
- Physiological Significance of Atrial Natriuretic Peptides in Essential Hypertension : SYMPOSIUM ON ATRIAL NATRIURETIC POLYPEPTIDE (ANP): Basic and Clinical Research : 51th Annual Scientific Session of the Japanese Circulation Society
- ASSESSMENT OF RECONSTRUCTION IMAGE OF THE HEART AND GREAT VESSELS OBTAINED FROM COMPUTED TOMOGRAPHY : Radio Isotope : 46th Annual Scientific Meeting, Japanese Circulation Society
- MULTIVARIATE ANALYSIS USING A LINEAR DISCRIMINANT FUNCTION FOR PREDICTING THE PROGNOSIS OF CONGESTIVE HEART FAILURE
- ARRHYTHMIAS IN WELL TRAINED ATHLETES : Arrhythmia : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- STURDY OF THE CARDIOVACULAR CHANGES AND THE PROGNOSIS OF HYPERTENSIVE PATIENTS TREATED WITH LONG-TERM ANTIHYPERTENSIVE REGIMEN : Cardiac Surgery II, Hemodialysis, Hypertension II : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese C
- PJ-270 Microbubble Destruction with Ultrasound Augments Neovascularization by Bone Marrow Cell Transplantation in Rat Hindlimb Ischemia(Peripheral circulation-7 (H) PJ46,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
- Effects of Cell Transplantation Using Vascular Endothelial Growth Factor-Expressing Mesenchymal Stem Cells for Myocardial Infarction(Acute Myocardial Infarction, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Beneficial Effect of Infarct-Related Artery Patency in Acute Anterior Myocardial Infarction in Patients With Poor Myocardial Viability in the Region-at-Risk
- Detecting Viable Myocardium and Predicting Functional Improvement : Comparisons of Positron Emission Tomography, Rest-Redistribution Thallium-201 Single-Photon Emission Computed Tomography (SPECT), Exercise Thallium-201 Reinjection SPECT, I-123 BMIPP SPEC
- The Long-Acting Ca^-Channel Blocker Azelnidipine Prevents Left Ventricular Remodeling After Myocardial Infarction
- Effects of Treatment for Diabetes Mellitus on Circulating Vascular Progenitor Cells
- The Effects of HMG-CoA Reductase Inhibitor on Vascular Progenitor Cells
- Effects of Erythropoietin on Cardiac Remodeling After Myocardial Infarction
- Granulocyte-Colony Stimulating Factor Augments Neovascularization Induced by Bone Marrow Transplantation in Rat Hindlimb Ischemia
- Angiotensin Blockade Inhibits Osteopontin Expression in Non-infarcted Myocardium After Myocardial Infarction
- HMG-CoA Reductase Inhibitor Increased Endothelial Progenitor Cells in Cultured Smooth Muscle Progenitor Cells (Lipid Disorders 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angiogenic Progenitor Cells in Patients with Diabetes Mellitus (Diabetes/Obesity 7 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angiotensin Blockades Inhibit Osteopontin Expression in Non-infarcted Myocardium after Myocardial Infarction(Old Myocardial Infarction/Remodeling 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Neutrophil Activation and Fibrin Formation in Intracoronary Thrombus Obtained from Patients with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Pathophysiology) 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation So
- Mid-band Lipoprotein Levels and Plasma Oxidized Low Density Lipoprotein Levels in Acute Myocardial Infarction versus Stable Angina Pectoris(Acute Coronary Syndrome, Basic/Clinical 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Soc
- Effects of Eplerenone on Transcriptional Factors and mRNA Expression Related to Cardiac Remodeling after Myocardial Infarction(Renin-angiotensin-aldosterone System (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Cardioprotective Effect of SEA0400, a Selective Inhibitor of the Na^+/Ca^ Exchanger, on Myocardial Ischemia-Reperfusion Injury in Rats
- STUDY ON THE INFLUENCING FACTORS ON THE PROGNOSIS IN CONGESTIVE HEART FAILURE (II) : Heart Failure : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -218-STUDY ON THE CLINICAL FEATURE OF THE HEART FAILURE CAUSED BY CHRONIC COR PULMONALE : Cardiac Failure : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- STUDY ON THE INFLUENCING FACTORS ON THE PROGNOSIS IN CONGESTIVE HEART FAILURE. : ESPECIALLY ON THE DISCRIMINANT ANALYSIS ACCORDING TO THE METHOD OF MULTIVARIATE STATISTICAL ANALYSIS : IInd Auditorium
- DIAGNOSIS OF ANEURYSM OF THE THORACIC AORTA BY NUCLEAR ANGIOCARDIOGRAPHY : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -1146-ROLE OF COMPLEMENT SYSTEM IN NONHYDROSTATIC PULMONARY CONGESTION IN ACUTE MYOCARDIAL INFARCTION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- STUDY ON THE DIAGNOSTIC SIGNIFICANCE OF THE P LOOP IN VCG FOR ASSESSMENT OF ATRIAL OVERLOADING (V) EVALUATION OF DIAGNOSTIC RELIABILITY OF THE P WAVE IN ORTHOGONAL ECG WITH FRANK LEAD SYSTEM : Ist Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE
- STUDY ON THE DIAGNOSTIC SIGNIFICANCE OF THE P LOOP IN VCG FOR ASSESSMENT OF ATRIAL OVERLOADING. (IV) : EVALUATION OF VECTORIAL AND SCALAR P COMPONENTS WITH FRANK LEAD SYSTEM
- PJ-556 Effects of aldosterone antagonist and angiotensin II type I receptor blocker on cardiac AP-1 and NF-κB in myocardial infarcted rat(Old myocardial Infarction/Remodeling 2 (IHD) : PJ93)(Poster Session (Japanese))
- PJ-044 Cell Transplantation for the Treatment of Acute Myocardial Infarction Using Vascular Endothelial Growth Factor-Expressing Mesenchymal Stem Cells(Acute Myocardial Infarction, Basic 2 (IHD) : PJ8)(Poster Session (Japanese))
- Granulocyte-Colony Stimulating Factor Augments Neovascularization Induced by Bone Marrow Transplantation in Rat Hind Limb Ischemia
- Angiotensin II Type-1 Receptor Antagonist as Well as Angiotensin Converying Enzyme Inhibitor Attenuates the Development of Heart Failure in Aortocaval Fistula Rats
- Myocardial Infarct Size by Serum Troponin T and Myosin Light Chain 1 Concentration
- Relationship Between Insufficient Redistribution in Exercise Thallium-201 Myocardial Single-photon Emission Computed Tomography and Reverse Redistribution at Rest
- COMPARISON OF THE EFFECTS OF DOBUTAMINE AND ISOPROTERENOL IN ISCHEMIC HEARTS BY PHOSPHORUS-31 NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
- ESTIMATION OF INFARCT SIZE USING SERUM TROPONIN T CONCENTRATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
- EVALUATION OF ^I-β-METHYL IODOPHENYL PENTADECANOIC ACID(BMIPP)IMAGING ON THE DETECTION OF ISCHEMIC HEART DISEASE : COMPARISON WITH ^Tl IMAGING
- EVALUATION OF MYOCARDIAL ISCHEMIA WITH INOTROPIC AGENTS BY PHOSPHORUS-31 NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
- Immunohistochemical Characteristics of Aspirated IntracoronaryThrombi in Acute Myocardial Infarction
- The effect of ascorbic acid on β-adrenergic-mediated bronchodilator responses in the presence of endogenous nitric oxide
- The effect of ascorbic acid on β-adrenergic-mediated bronchodilator responses in the presence of endogenous nitric oxide
- TIME COURSE OF THE RECOVERY OF ADENOSINE TRIPHOSPHATE CONTENT WITH DENOSINE IN POST-ISCHEMIC HEARTS : A ^P Magnetic Resonance Spectroscopy Study
- THE DELETERIOUS EFFECTS OF EXOGENOUS ANGIOTENSION I AND ANGIOTENSIN II ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY
- CLINICAL SIGNIFICANCE OF REVERSE REDISTRIBUTION ON THALLIUM-201 SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
- CIRCULATING ATRIAL NATRIURETIC POLYPEPTIDE IN RENAL DESEASE : Atrial Natriuretic Polypeptide (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CIRCULATING ATRIAL NATRIURETIC POLYPEPTIDE IN SHR AND HUMAN ESSENTIAL HYPERTENSION : Atrial Natriuretic Polypeptide (I) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Role of c-Jun NH_2 Terminal Kinase in G-Protein-Coupled Receptor Agonist-Induced Cardiac Plasminogen Activator Inhibitor-1 Gene Expression
- Involvement of c-Jun NH_2 Terminal Kinase and p38MAPK in Rapamycin-Mediated Inhibition of Neolntimal Formation in Balloon-Injured Rat Carotid Artery
- Patency in Acute Anterior Myocardial Infarction, in the Absence of Viable Myocardium in the Region-at-Risk
- Left ventricular-right atrial communication by perforation of the atrioventricular portion of the membranous septum and severe aortic valve regurgitation caused by infective endocarditis
- Cor triatriatum dexter with atrial septal defect evaluated by real-time three-dimensional transesophageal echocardiography