ACCELERATION OF CORONARY COLLATERAL DEVELOPMENT BY HEPARIN IN CONSCIOUS DOGS
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概要
- 論文の詳細を見る
We evaluated whether heparin pretreatment accelerates the development of coronary collateral vessels induced by repeated, brief coronary occlusions. Sixteen dogs were instrumented for the measurement of subendocardial segment length in the area perfused by the left circumflex coronary artery (LCCA), LCCA flow and left ventricular pressure. An externally inflatable pneumatic occluder was placed around the LCCA. Two min coronary occlusions (CO) at rest were repeated hourly until there was no reduction in ischemic segment systolic shortening at the end of CO and negligible reactive hyperemia following the release of CO. Eight control dogs developed collaterals sufficient for resting myocardial oxygen requirements in the LCCA region by 129±45 (SD) CO. The remaining 8 dogs given heparin daily developed collaterals by 81±33 CO (p<0.05). Thus, in the presence of severe myocardial ischemia known to promote collateralization, heparin accelerated the development of coronary collaterals.
- 社団法人日本循環器学会の論文
- 1987-04-20
著者
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Fujita Masatoshi
College of Medical Technology, Kyoto University
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Franklin Dean
Dalton Research Center University Of Missouri Columbia
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Franklin Dean
Dalton Research Center
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Fujita M
College Of Medical Technology Kyoto University
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Momose Atsushi
Dalton Research Center University Of Missouri-columbia
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FUJITA MASATOSHI
Dalton Research Center, University of Missouri-Columbia
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MIKUNIYA ATSUSHI
Dalton Research Center, University of Missouri-Columbia
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TAKAHASHI MASAAKI
Dalton Research Center, University of Missouri-Columbia
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GADDIS RONALD
Dalton Research Center, University of Missouri-Columbia
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HARTLEY JESSE
Dalton Research Center, University of Missouri-Columbia
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MCKOWN DANIEL
Dalton Research Center, University of Missouri-Columbia
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Mckown Daniel
Dalton Research Center University Of Missouri-columbia
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Takahashi Masaaki
Mie Pref. Institute Of Public Health & Environmental Science
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Gaddis Ronald
Dalton Research Center University Of Missouri-columbia
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Hartley Jesse
Dalton Research Center University Of Missouri-columbia
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Mikuniya Atushi
Hirosaki University School Of Medicine Second Internal Medicine
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