Effect of Angiotensin-Converting Enzyme Inhibition on Sympathetic Tone in Patients With Mild to Moderate Heart Failure
スポンサーリンク
概要
- 論文の詳細を見る
Sixteen patients with mild to moderate heart failure were examined to investigate whether sympathetic deactivation plays a role in the improvement in the failing heart by chronic angiotensin converting enzyme (ACE) inhibition. Measurements, including echocardiography, blood examinations, neurohumoral samplings (atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), norepinephrine), and spectral heart rate variability analysis by Holter electrocardiography, were carded out before and 6 months after the administration of lisinopril (5-10 mg/day). Quality of life assessment was accomplished by the Specific Activity Scale (SAS) questionnaire. Treatment with lisinopril for 6 months resulted in a significant reduction in systolic blood pressure. The left ventricular diastolic dimension significantly decreased and fractional shortening significantly increased on echocardiography. Of the 16 patients, 8 had improvement in their symptoms as measured by the SAS. Lisinopril did not significantly reduce the plasma norepinephrine concentration, but there was a significant reduction in the plasma ANP and BNP concentrations. In the heart rate power spectral analysis, total spectral power, high-frequency components and low/high frequency ratios did not change significantly with lisinopril. The mechanism by which ACE inhibitors improve mild to moderate heart failure is not by suppressing sympathetic activity.
- 社団法人日本循環器学会の論文
- 2001-04-20
著者
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KONISHI Takashi
Department of Polymer Science and Engineering, Faculty of Textile Science, Kyoto Institute of Techno
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Nakae Izuru
Department of Cardiology, Takeda Hospital
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Nakae Izuru
Department Of Cardiology Takeda Hospital
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Fujita Masatoshi
College of Medical Technology, Kyoto University
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Tamaki Shun-ichi
Department of Cardiology, Takeda Hospital
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Hashimoto Tetsuo
Department of Cardiology, Takeda Hospital
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Tamaki Shun-ichi
Department Of Cardiology Takeda Hospital
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Konishi Takashi
Department Of Cardiology Otsu Red Cross Hospital
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Konishi Takashi
Department Of Cardiology Tenri Hospital
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Watanuki Masato
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
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Fujita Masatoshi
College Of Medical Technology Kyoto University
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Inoko Moriaki
Division Of Cardiology Kitano Hospital
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Inoko Moriaki
Division Of Emergency Medicine Kyoto University Hospital
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Hashimoto Tetsuo
Department Of Cardiology Kouseikai Takeda Hospital
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Hashimoto Tetsuo
Department Of Cardiology Takeda General Hospital
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Watanuki Masato
Department Of Cardiology Good Samaritan Hospital
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Watanuki Masato
Department Of Cardiology Takeda General Hospital
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Hashimoto Tetsuo
Department Of Biosystems Science Graduate University For Advanced Studies (sokendai)
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