Intramyocardial Delivery of Basic Fibroblast Growth Factor-Impregnated Gelatin Hydrogel Microspheres Enhances Collateral Circulation to Infarcted Canine Myocardium

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概要

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• The present study examined whether basic fibroblast growth factor (bFGF)-impregnated acidic gelatin hydrogel microspheres (AGHM) would enhance collateral development to the infarct area in dogs with coronary occlusion. Studies were conducted in 28 dogs with a 2-week occlusion of the proximal left anterior descending coronary artery (LAD). The dogs were divided into 3 groups according to treatment: Group A treated with bFGF-impregnated AGHM in the infarct area; Group B with free-form bFGF; Group C with AGHM alone. Coronary angiography (n=15; Group A, 7 dogs; Group B, 5 dogs; Group C, 3 dogs) and a regional myocardial blood flow study (n=13; Group A, 6 dogs; Group B, 4 dogs; Group C, 3 dogs) were repeated at a 2-week interval. Coronary angiography revealed that in Group A, antegrade flow in the LAD distal to the occlusion, which was assessed by Thrombolysis in Myocardial Infarction (TIMI) grade, was significantly increased after treatment. In contrast, in Groups B and C, the treatment did not change the flow grade in the LAD. In Group A, the regional myocardial blood flow in the collateral dependent area was significantly increased after treatment, and the regional myocardial blood flow reserve after adenosine injection was also significantly increased. These measurements remained after treatment in Groups B and C. The immunohistochemical study with factor VIII-related antigen revealed an increase of vascular density in the ischemic region in Group A. Intramyocardial delivery of bFGF-impregnated AGHM, but not free-form bFGF, improves the collateral circulation to the infarct area of a coronary occlusion in dogs.

• 社団法人日本循環器学会の論文
• 2001-04-20

著者

• Okumura Ken

  Second Department Of Internal Medicine Hirosaki University

• Fujita Masatoshi

  College of Medical Technology, Kyoto University

• Hanada Hiroyuki

  Second Department of Internal Medicine, Hirosaki University School of Medicine

• Mikuniya Atsushi

  Second Department of Internal Medicine, Hirosaki University School of Medicine

• Yamamoto Takeru

  Second Department of Internal Medicine, Hirosaki University School of Medicine

• Suto Naoyuki

  Second Department of Internal medicine, Hirosaki University School of Medicine

• Okubo Tomoyuki

  Second Department of Internal medicine, Hirosaki University School of Medicine

• Okubo Tomoyuki

  Second Department Of Internal Medicine Hirosaki University School Of Medicine

• Mikuniya Atsushi

  Second Department Of Internal Medicine Hirosaki University School Of Medicine

• Fujita M

  College Of Medical Technology Kyoto University

• Okumura Ken

  Second Department Of Internal Medicine Hirosaki University School Of Medicine

• YAGIHASHI Soroku

  First Department of Pathology, Hirosaki University School of Medicine

• Fujita Masatoshi

  College Of Medical Technology Kyoto University

• Suto Naoyuki

  Second Department Of Internal Medicine Hirosaki University School Of Medicine

• Momose Atsushi

  Dalton Research Center University Of Missouri-columbia

• Hanada Hiroyuki

  Second Department Of Internal Medicine Hirosaki University School Of Medicine

• Mikuniya Atsushi

  The Medical Clinic Of Prof. Y. Oike Faculty Of Medicine Hirosaki University

• Mikuniya Atsushi

  Second Department Of Internal Medicine Hirosaki University

• Sutoh Naoyuki

  Department Of Cardiology Hirosaki University School Of Medicine

• Yamamoto Takeru

  Second Department Of Internal Medicine Hirosaki University School Of Medicine

• Yamamoto Takeru

  Department Of Cardiovaseular Medicine Aomori Central Hospital

• Momose Atsushi

  The Second Department Of Internal Medicine Hirosaki University School Of Medicine

• Okumura Ken

  The Division Of Cardiology Hirosaki University Graduate School Of Medicine

• Yagihashi Soroku

  First Department Of Pathology Hirosaki University School Of Medicine

• Yamamoto Takeru

  Second Department Of Internal Medicine Goshogawara City Seihoku Central Hospital

• Mikuniya Atushi

  The Second Department Of Internal Medicine Hirosaki University School Of Medicine.

• Okumura Ken

  Department Of Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of

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