Effects of Cardiac Sympathetic Nerve Stimulation on the Left Ventricular End-Systolic Pressure-Volume Relationship and Plasma Norepinephrine Dynamics in Dogs
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概要
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The effects of cardiac sympathetic nerve (CSN) stimulation on the left ventricular end-systolic pressure-volume relationship (ESPVR) and plasma norepinephrine (NE) concentration in arterial blood were studied in dogs. In 12 anesthetized and open-chest dogs, left ventricular pressure and volume were measured simultaneously with a microtip catheter and a conductance catheter, respectively. The ESPVR values were constructed from pressure-volume loops during a brief occlusion of the inferior vena cava before and after a 40-sec train of electrical CSN stimulation. The slope (E_<max>) of the ESPVR line was significantly greater after CSN stimulation than before CSN stimulation (p<0.05) for both right and left CSN stimulation. The increased E_<max> values after right and left CSN stimulation were not significantly different from each other. In 5 dogs, time courses of E_<max>, left ventricular systolic pressure, heart rate, and plasma NE concentration after CSN stimulation were studied. Left ventricular systolic pressure and heart rate returned to the baseline more rapidly than E_<max> and arterial plasma NE concentration. There was a positive, linear correlation between E_<max> (y) and arterial plasma NE concentration (x), shown as y=3.3×10^<-3>_X+3.1 (n=30, r=0.86, p<0.05). These results imply that cardiac contractile enhancement is reflected in arterial plasma NE concentration in conditions in which CSN is activated.
- 社団法人日本循環器学会の論文
- 1997-09-20
著者
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Okumura Ken
Second Department Of Internal Medicine Hirosaki University
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Murakami Masahiko
Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Mikuniya Atsushi
Second Department of Internal Medicine, Hirosaki University School of Medicine
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Shinozaki Nobuyo
Department of Radiological Technology, School of Allied Medical Sciences, Hirosaki University
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Suto Naoyuki
Second Department of Internal medicine, Hirosaki University School of Medicine
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Okubo Tomoyuki
Second Department of Internal medicine, Hirosaki University School of Medicine
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Okubo Tomoyuki
Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Mikuniya Atsushi
Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Okumura Ken
Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Suto Naoyuki
Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Momose Atsushi
Dalton Research Center University Of Missouri-columbia
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Mikuniya Atsushi
The Medical Clinic Of Prof. Y. Oike Faculty Of Medicine Hirosaki University
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Mikuniya Atsushi
Second Department Of Internal Medicine Hirosaki University
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Sutoh Naoyuki
Department Of Cardiology Hirosaki University School Of Medicine
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Momose Atsushi
The Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Okumura Ken
The Division Of Cardiology Hirosaki University Graduate School Of Medicine
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Shinozaki Nobuyo
Department Of Radiological Technology School Of Allied Medical Sciences Horosaki University
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Shinozaki Nobuyo
Department Of Radiological Technology School Of Allied Medical Sciences Hirosaki University
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Mikuniya Atushi
The Second Department Of Internal Medicine Hirosaki University School Of Medicine.
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Okumura Ken
Department Of Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of
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