Effect of Inferior Vena Cava Occlusion on Left Ventricular End-Systolic Pressure-Volume Relations in Intact Canine Hearts : Modulation by the Autonomic Nervous System

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The effect of inferior vena cava occlusion (IVCO) on end-systolic pressure-volume relations (ESPVR) of the left ventricle was studied in intact canine hearts. In 12 anesthetized open-chest dogs, left ventricular (LV) pressure and volume were measured simultaneously using a microtip catheter and a conductance catheter, respectively. ESPVR was constructed from LV pressure-volume loops during IVCO (10 sec) and subsequent IVCO release under 5 conditions: control, after righ or left cardiac sympathetic nerve (CSN) stimulation, bilateral vagotomy (VAT), and both VAT and bilateral CSN resection. E_<max> in IVCO relase was significantly greater than that in IVCO in the control state. Following right or left CSN stimulation, E_<max> was increased in both IVCO and IVCO release, with the same hysteretic change in E_<max>. With VAT, however, no hysteretic change was observed because E_<max> was the same in IVCO and IVCO relase. After VAT and CSN resection, E_<max> was decreased in both IVCO and IVCO release, and again no hysteretic change was observed. These data imply that a sudden decrease in venous return into the heart induces a decrease in afferent vagal nerve activity, and thus increases efferent CSN activity, resulting in enhanced myocardial contractility.
社団法人日本循環器学会の論文
1996-08-20