429 2 色レーザー誘起蛍光法を用いたグリオーマ検出法の開発

概要

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In the Brain surgery operation, it is important to completely resect glioma by operation, resulting in a long patient's. However, the malignant glioma-boundary is hard to see during operation, so a real-time monitoring system has been desirable. In this study, proposed is the novel photo-dynamic diagnosis method for glioma-surgery. The luminophor dye used in PDT can basically emit phosphorescence. The fluorescence intensity of auto-fluorescence can decrease in glioma. Using phosphorescence and auto-fluorescence images, the ratio-metric technique in Dual Emission Laser-Induced Fluorescence was applied to brain tumor detection. Consequently, it was confirmed that the contrast between tumor and normal region could be enhanced. Undesirable fluorescence variation, which was dependent on illumination intensity distribution and brain surface shape, could be reduced. The present method was clarified to be effective to brain tumor monitoring and quantitative delimitation.
社団法人日本機械学会の論文
2003-08-05