CGH法による脳腫瘍の細胞遺伝学的解析

概要

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Conparative genomic hybridization (CGH) is a technique which allowa the detection of losses and gains in DNA copy number along the entire genome. CGH wasused to study the genetic alterations in brain tumors. While 7p gain occurred exclusively in cases with the loss of all or part of chromosome 10, this change never occurred in cases having an increase in copy of 8q, which was the most frequently in younger patients than those with 7p gain. Our results provided evidence for distinct clinical manifestations in astrocytic tumors with 8q and7p gain. While typical meningiomas frequently displayed 22q loss, losses of 1p, 2p, 6q, chromosome 10and 14q, and gain of 20q were genetic changes implicated in the malignant progression of meningioma. While the most frequent aberration was loss of 13q with a minimal common overlapping region at 13q14 in pituitary adenomas, our results revealed that the mean number of sites of copy gain was significantly higher in functioning adenomas thanin non-functioning tumors. Further acquisition of genetic alterations were associated with unfavorable prognosis in patients with medulloblastomas. In this artcule, we discussed genetic alterations in brain tumors detected by CGH.
山口大学医学会の論文
1999-10-30