Xylofuranoside誘導体の抗アレルギー作用ないし抗炎症作用に関する基礎的研究(第1報)

概要

論文の詳細を見る
Anti-allergic and anti-inflamatory action of xylofuranoside derivatives were studied and the following results were obtained. l. No protective effect was observed in the cases of the severe passive anaphylaxis in the guinea pig (sensitized with about 8 times of antiserum required to produce fetal anaphylactic shock) by the pretreatment of the large amount of xylofuranoside derivatives; however, in the cases sensitized with antiserum just to produce fetal anaphylaxis a significant protective effect of the derivatives was observed. 2. The pretreatment of xylofuranoside to the passively sensitized mice seemed to be slightly effective against the fetal anaphylaxis in mice. 3. Xylofuranoside derivatives inhibited the in vitro contraction of the isolated guinea pig's ileum by the addition of histamine, acetylcholine, bradykinin and antigen; at the concentration of 100 mcg/ml of the derivatives, histamine, acetylcholine, bradykinin (0.1 mcg/ml) and anaphylactic contractions were completely inhibited and at the concentration of l0-30 mcg/ml incompletaly inhibited. 4. PCA reaction in the guinea pig was also slightly inhibited by the oral administration of the derivatives. 5. The inhibiting effect of the derivatives against the capillary and tissue permeability were also observed.
日本アレルギー学会の論文
1969-02-28