抗リンパ球血清に関する研究 : 第1編.抗マウス胸腺細胞血清の特異性

概要

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Anti-mouse thymocyte rabbit serum (ATRS), anti-lymphnode cell rabbit serum (ALRS) and anti-spleen cell rabbit serum (ASRS) were prepared, and comparative studies of the immune potency of these three anti-lymphocyte serum (ALS) were performed. Cytotoxic effect and leukoagglutination of ALS were observed by the new tissue culture technique. Each anti-serum unselectively destroyed thymocytes, lymphnode cells and spleen cells in vitro. Its potency decreased in the order of ALRS, ASRS and ATRS. The effect on the prolongation of the mean survival time of skin allograft was most prominent with ATRS. The grafted skins in the group of mice given ATRS which had the lowest antibody titer in vitro lived for 72.0 days on the average, and those given ALRS for 22.5 days and ASRS for 17.0 days respectively. A specific precipitating line was observed between ATRS and thymic abstractive fluid. It was supposed that the excellent inhibiting effects of ATRS on the homograft rejection might depend on the antagonistic action to the humoral factor derived from the thymus tissue.
日本アレルギー学会の論文
1969-09-30