本邦各地国立病院周辺地域にみられるアレルギー性疾患の研究

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On the characteristics of the allergic diseases in the environs of the associating national hospitals distributed in various districts of bur country, clinical studies were carried out, and the following results were brought about: 1) As to the unique allergic diseases in the surrounding areas of the hospitals that took part in our research group, the occupational asthma caused by mulberry lumber was newly found out among the craftsmen engaging in the wooden wares industry in the eastern bank of the Abe River of Shizuoka City. (Reporter: Susumu Nakamura) And the chrysanthemum allergy (dermatitis) was also noticed among the farmers cultivating chrysanthemum flowers in hot-house in the Atsumi district of Aichi Prefecture. (Reporter: Tatsuo Suga) 2) The intracutaneous test by inhalatory allergen extracts was carried out to each subject suffering from allergic diseases who visited the allergy clinic of the collaborated national hospitals. And the percentage of positive reaction to the test was calculated for the purpose of observing whether the regional differences in allergen substances were reflected in the percentage. a) In the cutaneous test by house dust allergen, positive reaction was observed in 809 of 1308 cases with asthma bronchiale (61.9%), in 183 of 411 cases with rhinitis allergica (44.5%), and in 15 of 29 cases with atopic dermatitis (51.7%). b) In regard to the cutaneous test by common inhalative allergens with the exception of house dust, positive reaction to the old mat, silk and cotton-wool was noticed in a high percentage, both in asthma bronchiale and in rhinitis allergica. As to the animal allergen, in asthma bronchiale, positive reaction to wool and cocoon was noticed in a high percentage, and to the hair of dogs and cats, the same was noticed by some reporters, too. But in rhinitis allergica, positive reaction except to cocoon was generally in a low percentage. And as to the vegetable allergen, positive reaction to buckwheat husks had a tendency that the easter a region of our country was located, the higher the percentage became. c) As to the pollen or mould, the percentage of positive reaction of the intracutaneous test differed considerably with the sorts of allergen or with the districts. From these observations it is conjectured that regional differences in the geographical distribution of allergen plants, and accordingly regional differences in the rise and fall of flying stage of air born pollen or mould, come into question. 3) Subsequently studies on the regional differences of the antigenicity of house dust were carried out. Hereupon, by means of checking up the positive reaction of intracutaneous test, the titer of selfprepared house dust extracts gathered from the houses of patients residing in the same region where the hospital was located was compared with that of the house dust extracts gathered from the houses of patients residing in two other regions. And little difference was noticed between the two. Judging from these observations, therefore, it is probable that the differences of the antigenicities of house dust extracts are rather derived from the specific character of each house than that of each region where the house dust was gathered.
日本アレルギー学会の論文
1969-06-30

本邦各地国立病院周辺地域にみられるアレルギー性疾患の研究

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