ピペット吸引法による遺伝性動脈硬化症(WHHL)ウサギ大動脈壁の局所弾性率計測 : 内圧負荷試験による計測との比較

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Local and global mechanical properties of atherosclerotic aorta were measured in 6 Watanabe heritable hyperlipidemic (WHHL) rabbits. Descending thoracic aortas were obtained from animals aged 8 months. Local initial elastic modulus E_<local> and global incremental elastic modulus H_<θθ> were measured with pipette aspiration technique and pressure diameter tests, respectively. Opening angles were measured as an index of residual strain. E_<local> of atherosclerotic lesion (fatty streak) was 19.1±1.9 kPa (mean±SEM), which was significantly smaller than that of preserved area (38.9±7.5 kPa). H_<θθ> of the whole specimen was 1 260±140 kl'a at 100 mmHg, and was not statistically different from the value measured in age matched controls, Japanese White rabbits. Opening angle was significantly larger in WHHL rabbits than in their controls. These results suggest that, in the early stages of atherosclerosis. (1) the lesion is more compliant than normal aortic tissues ; (2) macroscopic mechanical properties are not sensitive to local mechanical change ; (3) residual strain increases with the development of the disease. It is important to assess local mechanical properties and residual strain when studying mechanical properties of atherosclerotic aortas.
一般社団法人日本機械学会の論文
1999-08-25

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