Changes in Histological Construction and Decrease in 3H-QNB Binding in the Rat Brain after Prenatal X-irradiation
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概要
- 論文の詳細を見る
To elucidate the mechanisms involved in deleterious neuronal and behavioral changes after prenatal ionizing irradiation, in vitro muscarinic acetylcholine (mACh) receptor binding and histological construction were investigated in 9-week old rat brains after 1.5 Gy X-ray exposure on embryonic day 15 (E15). A gross anatomical examination with a magnetic-resonance imaging system showed an irregular tissue construction in the hippocampus and cortex of the irradiated rat brain. Histological sections stained with hematoxylin and eosin also indicated that the structures of the hippocampus and cortex were obviously changed. In irradiated rats, the laminar structure of pyramidal cells was selectively deranged in the CA1 region. In vitro ^3H-Quinuclidinyl benzilate binding in the hippocampus was significantly decreased (about 10%) in prenatal irradiated rats compared to that in sham-treated rats. On the other hand, no significant change in mACh receptor binding was observed in the cerebral cortex. The present study revealed that prenatal exposure to ionizing radiation may induce dysfunction of the cholinergic neuronal systems, especially in the hippocampus, resulting in deleterious changes in memory and behavior.
- 日本放射線影響学会の論文
著者
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INOUE Osamu
Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi
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HOSOI Rie
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
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Sun X‐z
National Inst. Of Radiological Sci. Chiba Jpn
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Sun Xue-zhi
徳島大学 医学部機能解剖学
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Takahashi Sentaro
Research Center For Radiation Safety National Institute Of Radiological Sciences
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Hosoi R
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Hosoi Rie
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Inoue O
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Inoue O
Central Research Laboratory Matsushita Electric Industrial Co. Ltd.
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Sun Xue-zhi
Brain Research Project National Institute Of Radiological Sciences
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Takai Nobuhiko
Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences
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MOMOSAKI Sotaro
Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences
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Momosaki Sotaro
Division Of Health Sciences Graduate School Of Medicine Osaka University
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Momosaki Sotaro
Department Of Brain Science And Molecular Imaging National Institute For Longevity Sciences
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Takahashi S
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Takai Nobuhiko
Department Of Molecular And Cellular Pharmacology Nagoya City University
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TAKAHASHI Sentaro
Brain Research Project, National Institute of Radiological Sciences
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TAKAI NOBUHIKO
Brain Research Project, National Institute of Radiological Sciences
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INOUE Osamu
Division of Health Sciences, Graduate School of Medicine, Osaka University
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Inoue O
Tohoku Rosai Hospital
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Takahashi Sentaro
Brain Research Project National Institute Of Radiological Sciences
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Inoue Osamu
Department Of Clinical And Laboratory Medicine Faculty Of Medicine University Of Yamanashi
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Inoue Osamu
Department of Chemistry, Faculty of Science, Toyama University
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