先天性第XIII因子欠乏症に伴った頭蓋内出血 : 1手術治験例と文献的考察

概要

論文の詳細を見る
A case of the intracranial hemorrhage due to the congenital factor XIII deficiency was experienced. The patient was a 27-year-old female, who had been diagnosed as congenital factor XIII deficiency at the age of 18. She presented acute consciousness disturbance and the left hemiplegia which was caused by a subcortical hemorrhage in the right frontal lobe. Removal of the hematoma through craniotomy was successfully carried out under a total of 1,500 units of factor XIII concentrate derived from human placenta, was followed by complete recovery without rebleeding or delay in wound-healing. Clinical features of the congenital factor XIII deficiency with intracranial hemorrhage were discussed with analysis of 27 cases including this case. Whenever a patient with intracranial hemorrhage is encountered, especially in case with a past history such as umbilical bleeding, posttraumatic hematoma, and defective wound-healing, congenital factor XIII deficiency must be borne in mind. Although intracranial hemorrhage is the most fatal complication with deficiency of coagulation factor XIII, the surgical treatment may be safe under replacement therapy of factor XIII concentrate derived from human placenta.
日本脳神経外科学会の論文
1985-09-15