Quantitative fluorescent PCR(QF-PCR)法を用いた胎児共存奇胎の解析

概要

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A complete hydatidiform mole coexisting with a normal fetus is rare, and accurate diagnosis is important due to the high potential for malignancy. We report two cases of hydatidiform mole coexisting with a normal fetus, and analyzed their genetic origin by quantitative fluorescent-PCR (QF-PCR) with short tandem repeat markers. One case revealed that the molar tissue was androgenetic and the fetus was of normal parental origin. In the other case, both the mola tissue and the fetus were of normal parental origin. QF-PCR is a reliable and accurate technique for the detection of the genetic origin of hydatidiform mole coexisting with a normal fetus.
社団法人日本産科婦人科学会の論文
2002-12-01