脾自家移植術の研究 : I 実験的検討

概要

論文の詳細を見る
The immunological effects of splenic autotransplantation after splenectomy remains uncertain. This experimental study concerns the change of platelet count and immunological function after splenic autotransplantation. Female BALE / C mice of six weeks after delivery were used. These mice were divided into 3 groups : laparotomy only (C) , total splenectomy (S) and total splenic autotransplantation after splenectomy (I). Each group was consisted of 5 mice. The groups of mice were sacrificed at 1, 3 days and 1, 2, 4, 6 and 8 weeks after the operation, then, platelet count, serum IgG, IgM level, lymphocyte subpopulation and mitogen response of the lymphocyte at mesenteric lymphonode were examined. The increase of platelet count in I was less than S during first postoperative week. This may suggest that the implanted spleen has some effect in preventing an increase in the platelet count after splenectomy. A decrease of serum IgM and Con A response was shown similarly in both S and I during the first 4 weeks postoperatively. However, recovery from these immunological supressions was found to be faster in I. A change in lymphocyte subpopulation was almost equal in S and I. Based on the results, the implanted spleen was considered to have some positive effects on the immune system.
特定非営利活動法人日本小児外科学会の論文
1990-02-20