ストレプトゾトシン誘発糖尿病ラットにおける八味地黄丸の効果

概要

論文の詳細を見る
The effects of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on the proteinuria, renal function and urinary excretion of nitric oxide were investigated in streptozotocin-induced diabetic nephropathic rats. In the diabetic rat model, urinary albumine excretion was higher, while urinary nitric oxide excretion was lower, compared to each in non-diabetic Sprague-Dawley rats. Administration of 0.8% Hachimi-jio-gan in the diet for 16 weeks to the diabetic rats resulted in decreasing urinary albumine excretion and increasing urinary nitric oxide excretion. Furthermore, the treatment decreased creatinine clearance and the ratio of renal glomerular tuft to Bowman's areas ; the increments of which suggest glomerular pressure increase. These results suggested that Hachimi-jio-gan possesses renal protective activity, and may be an effective remedy for the treatment of early-stage of diabetic nephropathy and the suppression of its progression.
和漢医薬学会の論文
2003-02-20