COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 13)EFFECTS OF A SINGLE ORAL DOSE OF CYCLOPHOSPHAMIDE
スポンサーリンク
概要
- 論文の詳細を見る
As part of a collaborative effort to evaluate whether effects on male reproductive organs of chemicals can be detected within two-week in toxicity studies, eight-week-old male Sprague-Dawley rats were given a single oral administration of 100 mg/kg of Cyclophosphamide (Cp), and sacrificed at 1, 3, 7 and 14 days thereafter. The numbers of seminiferous epithelial cells were counted in the seminiferous tubules of stages II-III, V, VII and XII of the spermatogenic cycle. Animals showed decreased spermatogonia at Day 3, decreased spermatogonia and preleptotene spermatocytes at Day 7, and decreased spermatogonia and zygotene spermatocytes at Day l4. We also detected decrease of zygotene spermatocytes on careful routine/traditional histopathological examination at Day l4. These results suggest that the testicular toxicity of Cp can be detected within two weeks after treatment with a sufficient dose in rats.
- 日本トキシコロジー学会の論文
- 2000-10-25
著者
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Sato Makoto
Dept.of Cardiology,Kokura Memorial Hosp
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SHIMOMOTO Takasumi
Department of Pathology, Sasaki Institute
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Kitaura K
Univ. Tokushima School Of Medicine Tokushima
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Kitaura Keisuke
Department Of Toxicology Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceuti
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MATSUMOTO Satoshi
Dept. of toxicology, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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HIRAKAWA Meiko
Dept. of toxicology, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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SHIMOMOTO Takasumi
Dept. of toxicology, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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KITAURA Keisuke
Dept. of toxicology, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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MINAMI Takanori
Dept. of toxicology, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
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Shimomoto Takasumi
Dept. Of Toxicology Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Sato Makoto
Department Of Toxicology Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceuti
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Hirakawa Meiko
Dept. Of Toxicology Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Kitaura K
Second Department Of Pathology The University Of Tokushima School Of Medicine
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Shimomoto Takasumi
Department Of Pathology Sasaki Institute
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Minami Takanori
Department Of Toxicology Drug Safety Research Center Tokushima Research Institute Otsuka Pharmaceuti
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Sato Makoto
Dept. Of Cardiology Kokura Memorial Hosp.
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Matsumoto Satoshi
Dept. Of Aeronautics And Space Engineering Tohoku Univ.
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Sato Makoto
Dept. Of Anatomy Ii Osaka Univ. Med. School
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