SODIUM N-[2-[4-(2, 2-DIMETHYLPROPIONYLOXY)PHENYLSULFONYLAMINO]BENZOYL]AMINOACETATE TETRAHYDRATE(ONO-5046・Na)の毒性試験(第4報)ラットにおける静脈内投与による6カ月間反復投与毒性試験および1カ月間回復試験

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A 6-month repeated dose toxicity syudy with 1-month recovery test of sodium N-[2-[4-(2, 2-dimethylpropionyloxy)phenylsulfonylamino]benzoyl]aminoacetate tetrahydrate(ONO-5046・Na), a novel neutrophil elastase inhibitor, was conducted in Sprague-Dawley(SD)rats. The rats of both sexes were administered ONO-5046・Na intravenously at a daily dose of 0(vehicle control), 18.75, 37.5 or 75 mg/kg. ONO-5046・Na did not affect clinical signs, body weight, food consumption, opthalmology, urinalysis, hematology, blood chemistry, organ weight, necropsy or histopathology at any dose. These results indicate that the NOAEL of ONO-5046・Na in rats is 75 mg/kg/day for both sexes in this study.
日本トキシコロジー学会の論文
1998-07-28