吸入液調製後の微生物汚染に対する保存剤の効果

概要

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The inhalant solutions used in inpatients were examined in our study to see if they exhabit microbial contaminations. Also, using hospital pharmacists and non-medical staffs as the study subjects, the same examination was carried out on the inhalant solutions prepared for the outpatients. As a result, the samples used in inpatients were all found to be free from contamination. The samples used in the pharmacists showed no sign of contamination, when they were first preserved in a dark, cool place (4℃). However, among the samples preserved in a dark place at room temperatures, the contamination by Acinetobacter sp. was detected in the preservative-free mixture of tyloxapol 0.125% and physiological saline. The samples of the same preservative-free mixture used in the non-medical staffs were observed to be contaminated with various microorganisms like Enterobacteriaceae, even when preserved in a dark, cool place (4℃). Judging from the findings we obtained, the cool and light resistant storage conditions alone cannot prevent inhalant solutions from microbial contaminations without the addition of appropriate preservatives. The microbial counts and species of the contaminants vary according to the handling and environmental conditions of inhalant solutions. Therefore, for the safe use of inhalant solutions in in- and outpatients, the addition of preservatives is thought to be essential.
日本医療薬学会の論文
1994-10-20