吸入液調製後の微生物汚染に関する考察

概要

論文の詳細を見る
The microbial contaminations of inhalant preparations, in which 2% orciprenalin sulfate solution and 0.2% bromhexine hydrocloride solution were mixed with sterile physiological saline (Prescription 1) and 0.125% tyloxapol solution was mixed with sterile physiological saline (Prescription 2), were investigated using two types of bottles on non-medical staffs assumed to be outpatients using inhalant preparations. As a result, each sample of Prescription 1, to which were added preservatives, was not contaminated either at room temperature under light protection or at a cool temperature under light protection. On the other hand, some samples of Prescription 2, which had no preservatives added, were contaminated with Pseudomonas sp., Flavobacterium sp. and Bacillus sp. over 10^2 CFU/ml. Accordingly, it was found that inhalant preparations cannot be prevented from microbial contamination without preservatives regardless of storage conditions and bottle types. Therefore, preservatives should be added to inhalant preparations to ensure their safe use without contamination.
日本医療薬学会の論文
1994-06-20