「抑うつ症」の治癒経過

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Thirty-one cases of "depression" were followed up for more than six months. The course of illness was retrospectively investigated. Our previous study disclosed that the chief symptoms and signs of "depression" were anorexia, insomnia, feeling not rested upon awakening, lassitude, plaintive facial expression, sadness and pessimism, lack of energy, and lowering of ability. In the present study the therapeutic effects of antidepressants on these eight symptoms and signs were indevidually examined over an average period of 13.5 weeks. No significant difference of duration necessary for im-provement was found among these eight symptoms and signs. Anorexia disappeared after 4.2 weeks first of all but lassitude after 6.8 weeks ultimately. It takes an average duration of 2.0 weeks medication that the initial effect began to appear. Within a week almost half the cases respond to the drugs used. Two-thirds of the patients had remission within three months. These facts suggest that the eight symptoms and signs of "depression" are not divisible but interact en masse. Depending on the length of medication, the patients were tentatively divided into two groups : less than three months (group A) and more than three months (group B). There was significant difference of duration nesessary for improvement of the symptoms and signs between the two except for anorexia and plaintive facil expression. Group B was significantly younger than group A in average. History reviewing revealed that previous depressed state was higher in group B than in group A, and that no difference existed as to diunal variation of symptoms and signs, cycloid temperament, and familial history of psychosis.
日本心身医学会の論文
1973-12-01

「抑うつ症」の治癒経過

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