血中濃度からみたジゴキシンの用量設定に関する現状分析と, 患者腎機能に対応した用量設定に向けての簡便な指標の構築

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To elucidate the current status of the dosage regimen of digoxin (DX), we reviewed its therapeutic drug monitoring (TDM) data obtained from 50 patients on whom TDM was performed for the first time following the beginning of DX treatment. The serum trough level of DX in 50 % the subjects deviated from its therapeutic range (0.5-1.5 ng/ml) because the uniform dosage (0.125- 0.148 mg/day) was administered for the patients with various degrees of renal functions. The serum levels of DX in about 70% of the patients with normal renal function (80 ml/min≦creatinine clearance. CLcr) were less than its lower limit (0.5 ng/ml), and those in about 70% of patients with severe abnormal renal function (CLcr<40 ml/min) exceeded its upper limit (1.5 ng/ml ). To design a simple index for the dosage regimen of DX whith closely corresponded to the renal functions in patients. 286 samples of TDM data obtained from 87 patients who were not coadministered drugs known to alter DX pharmacokinetics were reviewed by dividing then into three groups according to the CLcr values. The mean serum DX levels (0.7-1.2 ng/ml) in each group could be kept at their therapeutic range, as the dosages were respectively 0.25 mg/day (80≦CLcr group). 0.125-0.25 mg/day (40 ≦CLcr<80 group). or 0.0625-0.125 mg/day (CLcr<40 group ). These results indicate that the minimum dosages of DX in each reual function group, which were expected to maintain its effective serum level (0.7 ng/ml) within the lower limit of the therapeutic range, are desirable from a safety, that is, the optimal dosages of DX as an indication in the early dosing stage are respectively 0.25 mg/day for patients with normal renal function (80≦CLcr), 0.125 mg/day for patients with moderate abnormal renal function (40≦CLcr<80), and 0.0625 mg/day for patients with severe abnormal renal functicn (CLcr<40).
日本医療薬学会の論文
1998-08-10

血中濃度からみたジゴキシンの用量設定に関する現状分析と, 患者腎機能に対応した用量設定に向けての簡便な指標の構築

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