医療用漢方エキス製剤に関する研究 : 医療用葛根湯エキス製剤及び小青竜湯エキス製剤中の有効成分含有量

概要

論文の詳細を見る
The contents of glycyrrhizin, paeoniflorin, and ephedrine as common indicator components to commercially available kakkon-to and Sho-seiryu-to extract preparations were determined. In addition, the content of the active ingredient schizandrin of known pharmacological action in the Sho-seiryu-to extract preparations was also determined. The contents of glycyrrhizin, paeoniflorin, and ephedrine varied from one brand to another of the kakkon-to and Sho-seiryu-to extract preparations (p<0.01). The content of paeoniflorin, in particular, in the kakkon-to extract preparations widely ranged from 37.3 mg to 75.2 mg (p<0.01). The content of ephedrine in these some preparations also markedly ranged from 8.5 mg to 20.9 mg (p<0.01). On the other hand, the content of ephedrine in the Sho-seiryu-to extract preparations markedly changed from lot to lot with some brands. The content of schizandrin showed a pronounced variation among brands of these preparations (p<0.01). These results indicate the need for establishing proper standards of formulation medicines and the specification of the content of active ingredients other than the indicator components.
日本医療薬学会の論文
1996-10-10