注射剤からのブプレノルフィン坐剤の調製とその臨床応用

概要

論文の詳細を見る
Buprenorphine (BN) is a long-lasting, low-dependent and non-narcotic analgesic, which is effectively employed against various pains, such as cancer, myocardiac and postoperative pain. However, since BN was used only as an injection in Japan, we have planned to adapt it for suppository use for patients who cannot take oral drugs or for home therapy. A method of freeze-drying of the BN injection was chosen on the basis of its simplicity and reproducibility over other methods. With this method, we prepared both a water-soluble, polyethylene glycol based suppository (200.1±1.51μg, n=5) and an oil-soluble, witepsol based suppository (200.8±1.70μg, n=5). The physical characteristics of each suppository were examined with regard to the pharmaceutical items of weight, BN content, hardness, melting point, liquefaction time and dissolution. In the clinical cross-over test, the rectal administration of both types of suppository showed equally good results.
日本医療薬学会の論文
1990-04-20