塩化リゾチーム軟膏(リフラップ^<[○!R]>軟膏)の配合変化(第2報)

概要

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Compatibility tests of lysozyme chloride ointment (Reflap^<[○!R]> Ointment) with eleven anti-micro-bial agents and four disinfectants were carried out. Reflap^<[○!R]> ointment was mixed with other ointments and creams in equal weight. A day's dose of anti-microbial injections and 5ml disinfectant solutions were, respectively, mixed with 30g Reflap^<[○!R]> ointment. The mixtures in polyethylene airtight vessels were stored at room temperature for two months. Changes of appearance (e.g., color, odor and bleeding), pH level and lysozyme activity were studied. It was found that the significant reductions of lysozyme activity immediately occurred in the cases of the mixture with Chloromycetin^<[○!R]> ointment or Isodine^<[○!R]> gel. The lysozyme activity were reduced with time in the cases of the mixture with Terra-Cortril^<[○!R]> ointment, Fucidin leo^<[○!R]> ointment and Lilacillin^<[○!R]> injection. No changes were observed in any of the other mixtures.
1989-08-20