塩化リゾチーム軟膏(リフラップ^<[○!R]>軟膏)の配合変化(第1報)

概要

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Compatibility tests of lysozyme chloride ointment (Reflap^<[○!R]> ointment) with nine anti-skin ulcer agents and seven steroidal agents were carried out. Reflap^<[○!R]> ointment was mixed with other ointments and creams in equal weight. And 1g external powder was mixed with 30g Reflap^<[○!R]> ointment. The mixtures in polyethylene airtight vessels were stored at room temperature for two months. Changes of appearance (e.g., color, odor and bleeding), pH level and lysozyme activity were studied. It was found that the oil phase was slightly separated in the mixture with Elase^<[○!R]> ointment. The surface color of the mixture with Geben^<[○!R]> cream was changed from white to grayish-purple. But Lysozyme activities were not changed in the both cases. In the cases of the mixture with Zildasac^<[○!R]> ointment and Trianopollon^<[○!R]> cream, the significant reductions of Lysozyme activity immediately occurred. No other changes were observed in any of the other mixtures.
1989-08-20